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Asociación entre hiponatremia, mortalidad y estancia hospitalaria en pacientes con falla cardíaca descompensada

dc.contributor.authorDiaztagle Fernández, Juan Joséspa
dc.contributor.authorChaves Saltiago, Walter Gabrielspa
dc.contributor.authorSprockel Díaz, John Jaimespa
dc.contributor.authorAcevedo Velasco, Andrés Davidspa
dc.contributor.authorRodríguez Benítez, Fredy Hernánspa
dc.contributor.authorBenavides Solarte, Mario Fernandospa
dc.contributor.authorRodríguez Niño, María Angélicaspa
dc.contributor.authorVillamizar Quintero, Álvaro Joséspa
dc.contributor.authorBotero Jaramillo, Giovannaspa
dc.contributor.authorPlazas Vargas, Francy Lilianaspa
dc.date.accessioned2020-10-27T14:19:17Z
dc.date.available2020-10-27T14:19:17Z
dc.date.issued2019-11-29
dc.identifier.issn2382-4603
dc.identifier.issn0123-7047
dc.identifier.urihttp://hdl.handle.net/20.500.12749/9919
dc.description.abstractIntroducción. La hiponatremia es la alteración electrolítica más frecuente en pacientes con falla cardíaca crónica, que afecta hasta el 28% de pacientes en el ingreso hospilatario. Se ha demostrado que es un predictor independiente de mortalidad, estancia prolongada y rehospitalización. El objetivo es describir la frecuencia de hiponatremia en pacientes con falla cardíaca descompensada y su relación con la estancia hospitalaria y mortalidad. Metodología. Cohorte prospectiva en pacientes hospitalizados por el servicio de Medicina Interna en un hospital de cuarto nivel de Bogotá, Colombia, con diagnóstico de falla cardíaca descompensada entre abril de 2011 y marzo de 2012. Se midió el sodio al ingreso, a las 72 horas y al día séptimo de hospitalización. Se evaluó la relación de la hiponatremia al ingreso con la estancia hospitalaria y la mortalidad intrahospitalaria a 30 días. Resultados. Se incluyeron 162 pacientes, con promedio de edad de 72 años, 52.5% hombres. Cuarenta y uno (25.3%) presentaron hiponatremia al ingreso. Entre los pacientes que presentaron sodio normal al ingreso, 6 presentaron hiponatremia a las 72 horas y 2 a los 7 días. La mortalidad intrahospitalaria en la población total fue 9.2%, en el grupo de hiponatremia 12.2%, y 8.2% en los que no la tuvieron (p= 0.45). El promedio de estancia hospitalaria fue superior en los pacientes con hiponatremia, 6.6 vs. 8.4 días (p= 0.12). Discusión. La incidencia de hiponatremia al ingreso en este grupo de pacientes fue semejante a la reportada en la literatura. Conclusiones. Existe una tendencia hacia una mayor mortalidad y estancia hospitalaria en pacientes con hiponatremia, aun cuando no fue estadísticamente significativa.spa
dc.format.mimetypeapplication/pdfspa
dc.format.mimetypeApplication/pdfspa
dc.format.mimetypeText/xmlspa
dc.language.isospaspa
dc.language.isoengspa
dc.publisherUniversidad Autónoma de Bucaramanga UNAB
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/3497/3146
dc.relationHttps://revistas.unab.edu.co/index.php/medunab/article/view/3497/3147
dc.relationHttps://revistas.unab.edu.co/index.php/medunab/article/view/3497/3171
dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/article/view/3497
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceMedUNAB; Vol. 22 Núm. 3 (2019): diciembre 2019 - marzo 2020: Dolor oncológico, Falla cardíaca, Obesidad; 294-303
dc.titleAsociación entre hiponatremia, mortalidad y estancia hospitalaria en pacientes con falla cardíaca descompensada
dc.title.translatedAssociation between hyponatremia, mortality and hospitalization in patients with acute decompensated Heart Failureeng
dc.title.translatedAssociação entre hiponatremia, mortalidade e internação hospitalar em pacientes com insuficiência cardíaca descompensadaport
dc.publisher.facultyFacultad Ciencias de la Salud
dc.publisher.programPregrado Medicina
dc.type.driverinfo:eu-repo/semantics/article
dc.type.localArtículospa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.subject.keywordsHeart failureeng
dc.subject.keywordsHyponatremiaeng
dc.subject.keywordsPrognosiseng
dc.subject.keywordsMortalityeng
dc.subject.keywordsHospitalizationeng
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.type.hasversionIinfo:eu-repo/semantics/acceptedVersion
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.relation.referencesPark J, Cho Y, Oh I, Park H, Lee H, Kim K et al. Short and long-term prognostic value of hyponatremia in heart failure with preserved ejection fraction versus reduced ejection fraction: An analysis of the Korean Acute Heart Failure registry. International Journal of Cardiology. 2017;248:239-245. Disponible en https://doi.org//10.1016/j.ijcard.2017.08.004
dc.relation.referencesLu D, Cheng H, Cheng Y, Hsu P, Huang W, Guo C et al. Hyponatremia and Worsening Sodium Levels Are Associated With Long‐Term Outcome in Patients Hospitalized for Acute Heart Failure. Journal of the American Heart Association. 2016;5(3):e002668. Disponible en https://doi.org//10.1161/JAHA.115.002668
dc.relation.referencesOmar H, Charnigo R, Guglin M. Prognostic Significance of Discharge Hyponatremia in Heart Failure Patients With Normal Admission Sodium (from the ESCAPE Trial). The American Journal of Cardiology. 2017;120(4):607-615. Disponible en https://doi.org//10.1016/j.amjcard.2017.05.030
dc.relation.referencesChouihed T, Buessler A, Bassand A, Jaeger D, Virion J, Nace L et al. Hyponatraemia, hyperglycaemia and worsening renal function at first blood sample on emergency department admission as predictors of in-hospital death in patients with dyspnoea with suspected acute heart failure: retrospective observational analysis of the PARADISE cohort. Emergency Medicine. 2019. Disponible en https://doi.org//10.1136/bmjopen-2017-019557
dc.relation.referencesSaepudin S, Ball P, Morrissey H. Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure. BMC Cardiovascular Disorders. 2015;15(1). Disponible en https://doi.org//10.1186/s12872-015-0082-5
dc.relation.referencesVerbrugge F, Grodin J, Mullens W, Taylor D, Starling R, Tang W. Transient Hyponatremia During Hospitalization for Acute Heart Failure. The American Journal of Medicine. 2016;129(6):620-627. Disponible en https://doi.org//10.1016/j.amjmed.2016.01.016
dc.relation.referencesSica DA. Sodium and water retention in heart failure and diuretic therapy: basic mechanisms. Cleve Clin J Med. 2006;73 Suppl 2:S2-7; discussion S30-3
dc.relation.referencesRomanovsky A, Bagshaw S, Rosner MH. Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy. Int J Nephrol. 2011; 2011: 732746. Disponible en https://doi.org//10.4061/2011/732746
dc.relation.referencesSica DA. Hyponatremia and heart failure--pathophysiology and implications. Congest Heart Fail. 2005;11(5):274-7. Disponible en https://doi.org//10.1111/j.1527-5299.2005.04180.
dc.relation.referencesLee CR, Watkins ML, Patterson JH, Gattis W, O’Connor CM, Gheorghiade M, et al. Vasopressin: a new target for the treatment of heart failure. Am Heart J. 2003;146(1):9-18. Disponible en https://doi.org//10.1016/S0002-8703(02)94708-3
dc.relation.referencesSpital A. Diuretic-induced hyponatremia. Am J Nephrol. 1999;19(4):447-52. Disponible en https://doi.org//10.1159/000013496
dc.relation.referencesAhmed A, Husain A, Love TE, Gambassi G, Dell’Italia LJ, Francis GS, et al. Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods. Eur Heart J. 2006;27(12):1431-9. Disponible en https://doi.org//10.1093/eurheartj/ehi890
dc.relation.referencesYamazoe M, Mizuno A, Kohsaka S, Shiraishi Y, Kohno T, Goda A et al. Incidence of hospital-acquired hyponatremia by the dose and type of diuretics among patients with acute heart failure and its association with long-term outcomes. Journal of Cardiology. 2018;71(6):550-556. Disponible en https://doi.org//10.1016/j.jjcc.2017.09.015
dc.relation.referencesLee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation. 1986;73(2):257-67
dc.relation.referencesGheorghiade M, Rossi JS, Cotts W, Shin DD, Hellkamp AS, Pina IL, et al. Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE Trial. Arch Intern Med. 2007;167(18):1998-2005. Disponible en https://doi.org//10.1001/archinte.167.18.1998
dc.relation.referencesRossi J, Bayram M, Udelson JE, Lloyd-Jones D, Adams KF, Oconnor CM, et al. Improvement in hyponatremia during hospitalization for worsening heart failure is associated with improved outcomes: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) trial. Acute Card Care. 2007;9(2):82-6. Disponible en https://doi.org//10.1080/17482940701210179
dc.relation.referencesRusinaru D, Buiciuc O, Leborgne L, Slama M, Massy Z, Tribouilloy C. Relation of Serum Sodium Level to Long-Term Outcome After a First Hospitalization for Heart Failure with Preserved Ejection Fraction. Am J Cardiol. 2009;103:405-410. Disponible en https://doi.org//10.1016/j.amjcard.2008.09.091
dc.relation.referencesCampo RL, Acosta RE, Gómez EA. Correlación entre los valores de sodio y el N terminal propéptido natriurético cerebral en pacientes con falla cardíaca descompensada. Rev Col Cardiol. 2012:19(Supl 1):39
dc.relation.referencesChaves W, Diaztagle J, Sprockel J, Hernández J, Benavidez J, Henao D et al. Factores asociados a mortalidad en pacientes con falla cardíaca descompensada. Acta Med Colomb. 2014;39(4):314-320
dc.relation.referencesCiapponi A, Alcaraz A, Calderón M, Matta MG, Chaparro M, Soto N, Bardach A. Carga de enfermedad de la insuficiencia cardiaca en América Latina: revisión sistemática y metanálisis. Rev Esp Cardiol. 2016;69(11):1051-1060
dc.relation.referencesDiaztagle-Fernández JJ, Latorre-Alfonso SI, Maldonado-Arenas SE, Manosalva-Álvarez GP, Merchán-Cepeda JS, Centeno-García CD, et al. La investigación en falla cardíaca en Colombia 1980-2015: una revisión sistemática. Rev. Fac. Med. 2018;66(2):139-51. doi: http://dx.doi.org/10.15446/revfacmed.v66n2.60005
dc.relation.referencesMcKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med. 1971;285(26):1441-6
dc.relation.referencesOren RM. Hyponatremia in congestive heart failure. Am J Cardiol. 2005;95:2B-7B
dc.relation.referencesGheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O’Connor CM, et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J. 2007;28(8):980-8. Disponible en https://doi.org//10.1093/eurheartj/ehl542
dc.relation.referencesPatel Y, Kurgansky K, Imran T, Orkaby A, McLean R, Ho Y et al. Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association. 2018;7(12):1-13. Disponible en https://doi.org//10.1161/JAHA.117.007529
dc.relation.referencesSato N, Gheorghiade M, Kajimoto K, Munakata R, Minami Y, Mizuno M, et al. Hyponatremia and In-Hospital Mortality in Patients Admitted for Heart Failure (from the ATTEND Registry). Am J Cardiol. 2013;111:1019-1025. Disponible en https://doi.org//10.1016/j.amjcard.2012.12.019
dc.relation.referencesJao GT, Chiong JR. Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options. Clin Cardiol. 2010;33(11):666-71. Disponible en https://doi.org//10.1002/clc.20822
dc.relation.referencesKlein L, O’Connor CM, Leimberger JD, Gattis-Stough W, Pina IL, Felker GM, et al. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation. 2005;111(19):2454-60. Disponible en https://doi.org//10.1161/01.CIR.0000165065.82609.3D
dc.relation.referencesShchekochikhin D, Schrier R, Lindenfeld J, Price L, Jaber B, Madias N. Outcome Differences in Community- Versus Hospital- Acquired Hyponatremia in Patients With a Diagnosis of Heart Failure. Circ Heart Fail. 2013;6:379-386. Disponible en https://doi.org//10.1161/CIRCHEARTFAILURE.112.000106
dc.contributor.cvlacDiaztagle Fernández, Juan José [0000-0002-0320-8304]
dc.contributor.cvlacChaves Saltiago, Walter Gabriel [0001444376]
dc.contributor.cvlacSprockel Díaz, John Jaime [0001448981]
dc.contributor.cvlacAcevedo Velasco, Andrés David [0000018508]
dc.contributor.cvlacBenavides Solarte, Mario Fernando [0001689669]
dc.contributor.cvlacVillamizar Quintero, Álvaro José [0001369507]
dc.contributor.cvlacBotero Jaramillo, Giovanna [0000134422]
dc.contributor.orcidSprockel Díaz, John Jaime [0000-0002-7021-6769]
dc.contributor.orcidBotero Jaramillo, Giovanna [0000-0003-0085-253X]
dc.subject.lembCiencias de la salud
dc.subject.lembMedicina
dc.subject.lembCiencias de la vida
dc.identifier.repourlrepourl:https://repository.unab.edu.co
dc.description.abstractenglishIntroduction. Hyponatremia is the most common electrolyte disorder in patients with chronic heart failure affecting up to 28% of patients at admission. It has been shown to be an independent predictor of mortality, extended length of hospital stay and rehospitalization. The objective is to evaluate the presence of hyponatremia in patients with decompensated heart failure and describe its relationship with length of hospital stay and mortality. Methodology. A prospective cohort study in patients hospitalized at internal medicine service at a high level of complexity hospital in Bogotá, Colombia diagnosed with decompensated heart failure between April 2011 and March 2012. Sodium was measured on admission, 72 hours and at the seventh day of hospitalization. We evaluated the association between hyponatremia at hospital admission, mortality at 30 days and length of hospital stay. Results. 162 patients were included with an average age of 72 years, 52.5% male. Forty-one (25.3%) had hyponatremia at admission. Among the patients with normal sodium at admission, 6 had hyponatremia at 72 hours and 2 at the seventh day. In-hospital mortality in the total population was 9.2%, in the hyponatremia group 12.2%, and 8.2% in those who did not have it (p = 0.45). The average length of hospital stay was higher in patients with hyponatremia, 6.6 vs 8.4 days (p = 0.12). Discussion. The incidence of hyponatremia at admission in this group of patients was similar to that reported in the literature. Conclusions. The results showed a trend towards higher mortality and hospital stay in patients with hyponatremia, even though it was not statistically significant.eng
dc.description.abstractotherIntrodução. A hiponatremia é o desequilíbrio hidroeletrolítico mais frequente em pacientes com insuficiência cardíaca crônica, que afeta até 28% dos pacientes internados. Demonstrou ser um preditor independente de mortalidade, permanência prolongada e re-internação. O objetivo é descrever a frequência de hiponatremia em pacientes com insuficiência cardíaca descompensada e sua relação com internação hospitalar e mortalidade. Metodologia.Coorte prospectiva em pacientes internados pelo serviço de Medicina Interna em um hospital de quarto nível em Bogotá, Colômbia, com diagnóstico de insuficiência cardíaca descompensada, entre abril de 2011 e março de 2012. Foi medido o sódio na admissão, às 72 horas e no sétimo dia de internação. Foi avaliada a relação de hiponatremia na admissão com internação e a mortalidade hospitalar aos 30 dias. Resultados. Foram incluídos 162 pacientes, com idade média de 72 anos, 52,5% homens. Quarenta e um (25,3%) apresentaram hiponatremia na admissão. Entre os pacientes que apresentaram sódio normal na admissão, seis apresentaram hiponatremia às 72 horas, e dois aos sete dias. A mortalidade hospitalar na população total foi de 9,2%, no grupo de hiponatremia 12,2% e 8,2% naqueles que não apresentaram (p = 0,45). O tempo médio de internação foi maior nos pacientes com hiponatremia, 6,6 vs. 8,4 dias (p = 0,12). Discussão. A incidência de hiponatremia na admissão nesse grupo de pacientes foi semelhante à relatada na literatura. Conclusões. Existe uma tendência de maior mortalidade e permanência hospitalar em pacientes com hiponatremia, mesmo que não tenha sido estatisticamente significante.port
dc.subject.proposalInsuficiencia cardíaca
dc.subject.proposalHiponatremia
dc.subject.proposalPronóstico
dc.subject.proposalMortalidad
dc.subject.proposalHospitalización
dc.identifier.doi10.29375/01237047.3497
dc.type.redcolhttp://purl.org/redcol/resource_type/ART


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