Mostrar el registro sencillo del ítem
Determinación de los factores asociados con la pérdida endotelial a 5 años de seguimiento y el resultado refractivo en pacientes con lente fáquico artisan: Estudio longitudinal
dc.contributor.advisor | Tello Hernández, Alejandro | spa |
dc.contributor.advisor | Galvis Ramírez, Virgilio | spa |
dc.contributor.author | Acuña Vesga, María Fernanda | spa |
dc.date.accessioned | 2020-06-26T20:01:42Z | |
dc.date.available | 2020-06-26T20:01:42Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12749/1786 | |
dc.description.abstract | El implante de lentes fáquicos como el lente Artisan es una de las alternativas quirúrgicas para mejorar la agudeza visual en los pacientes en quienes no está indicada la corrección por medio de procedimientos con Excimer Láser, como son: pacientes con defectos refractivos altos (miopía, hipermetropía y astigmatismo), córneas delgadas, muy curvas o muy planas. El número de pacientes a los que se les ha implantado el lente Artisan (lente fáquico de apoyo en el iris) se ha incrementado de manera progresiva en la última década, pero existen pocos estudios que nos determinen los desenlaces a largo plazo (5 años o más) en cuanto a resultados refractivos y posibles complicaciones postoperatorias tardías (incluyendo la pérdida endotelial corneal). Las células endoteliales son las encargadas por medios de sus bombas metabólicas de mantener la córnea en un estado de hidratación estable para que el porcentaje de dispersión de la luz sea mínimo y el tejido corneal tenga la transparencia requerida(1,2). La densidad de estas células endoteliales es pues crítica para esa función. El endotelio corneal en el humano es un tejido que carece casi totalmente de actividad mitótica in vivo(3), por lo cual cualquier tipo de procedimiento quirúrgico intraocular implica algún tipo de trauma a nivel endotelial, con posible disminución de su población. Por ello es importante estimar el porcentaje de pérdida de células endoteliales posterior al implante de lentes fáquicos de apoyo en iris, que sumado con el porcentaje de pérdida normal aproximado secundario al envejecimiento de la córnea, nos daría la pérdida total de células endoteliales. Se espera que este porcentaje de pérdida sea un indicador de seguridad a largo plazo del procedimiento. El objetivo de nuestro estudio fue evaluar la seguridad y eficacia del implante del lente Artisan fáquico, y específicamente estudiar de manera detallada la seguridad con respecto a la pérdida endotelial corneal postoperatoria. Al tratarse de una población joven y con una gran posibilidad de mantener el lente implantado por mayor tiempo (4 o más décadas), hace que sea importante determinar a largo plazo que tanta pérdida de células endoteliales se puede presentar y así mejorar los criterios de inclusión para los pacientes que son posibles candidatos para el implante. | spa |
dc.description.tableofcontents | MARCO TEÓRICO ESTADO DEL ARTE OBJETIVOS METODOLOGÍA CONSIDERACIONES ÉTICAS RESULTADOS DISCUSIÓN CONCLUSIONES BIBLIOGRAFÍA ANEXOS | |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | * |
dc.title | Determinación de los factores asociados con la pérdida endotelial a 5 años de seguimiento y el resultado refractivo en pacientes con lente fáquico artisan: Estudio longitudinal | spa |
dc.title.translated | Determination of factors associated with endothelial loss at 5 years of follow-up and refractive outcome in patients with artisan phakic lens: Lngitudinal study | eng |
dc.degree.name | Especialista en Oftalmología | spa |
dc.coverage | Bucaramanga (Colombia) | spa |
dc.publisher.grantor | Universidad Autónoma de Bucaramanga UNAB | spa |
dc.rights.local | Abierto (Texto Completo) | spa |
dc.publisher.faculty | Facultad Ciencias de la Salud | spa |
dc.publisher.program | Especialización en Oftalmología | spa |
dc.description.degreelevel | Especialización | spa |
dc.type.driver | info:eu-repo/semantics/masterThesis | |
dc.type.local | Tesis | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | |
dc.subject.keywords | Eye abnormalities | eng |
dc.subject.keywords | Phakic Lenses | eng |
dc.subject.keywords | Iridocorneal endothelial syndrome | eng |
dc.subject.keywords | Medicine | eng |
dc.subject.keywords | Ophthalmology | eng |
dc.subject.keywords | Research | eng |
dc.subject.keywords | Ophthalmic lenses | eng |
dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga - UNAB | spa |
dc.identifier.reponame | reponame:Repositorio Institucional UNAB | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
dc.relation.references | Acuña Vesga, María Fernanda (2018). Determinación de los factores asociados con la pérdida endotelial a 5 años de seguimiento y el resultado refractivo en pacientes con lente fáquico artisan: estudio longitudinal. Bucaramanga (Colombia) : Universidad Autónoma de Bucaramanga UNAB | spa |
dc.relation.references | Krachmer JH, Mannis MJ, Holland EJ. Cornea. Mosby/Elsevier; 2011. 54 p. | |
dc.relation.references | Benedetti S, Casamenti V, Benedetti M. Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia. Five-year study. J Cataract Refract Surg. 2007;33(5):784–90. | |
dc.relation.references | Krachmer JH, Mannis MJ, Holland EJ. Cornea. Mosby/Elsevier; 2011. 54 p. | |
dc.relation.references | Saxena R, Boekhoorn SS, Mulder PGH, Noordzij B, van Rij G, Luyten GPM. Long-term Follow-up of Endothelial Cell Change after Artisan Phakic Intraocular Lens Implantation. Ophthalmology. 2008;115(4):7–9. | |
dc.relation.references | Comaish IF, Lawless MA. Phakic intraocular lenses. Curr Opin Ophthalmol. 2002;13(1):7–13. | |
dc.relation.references | Chang DH, Davis EA. Phakic intraocular lenses. Curr Opin Ophthalmol. 2006;17(1):99–104 | |
dc.relation.references | Malecaze francois JH, , Hulin. BIerer P. A Randomized Paired Eye Comparison of Two Techniques for Treating Moderately High Myopia. 2002;6420(02):1622–30. | |
dc.relation.references | Lifshitz T, Levy J, Aizenman I, Klemperer I, Levinger S. Artisan phakic intraocular lens for correcting high myopia. Int Ophthalmol. 2005;25(4):233–8. | |
dc.relation.references | Maloney RK, Nguyen LH, John ME. Artisan phakic intraocular lens for myopia: Short-term results of a prospective, multicenter study. Ophthalmology. 2002;109(9):1631–41. | |
dc.relation.references | Bouheraoua N, Bonnet C, Labbé A, Sandali O, Lecuen N, Ameline B, et al. Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss. J Cataract Refract Surg. 2015;41(11):2450–7. | |
dc.relation.references | Silva RA, Jain A, Manche EE. Prospective long-term evaluation of the efficacy, safety, and stability of the phakic intraocular lens for high myopia. Arch Ophthalmol. 2008;126(6):775–81. | |
dc.relation.references | Titiyal JS, Sharma N, Mannan R, Pruthi A, Vajpayee RB. Iris-fixated intraocular lens implantation to correct moderate to high myopia in Asian-Indian eyes: Five-year results. J Cataract Refract Surg [Internet]. 2012;38(8):1446–52. Available from: http://dx.doi.org/10.1016/j.jcrs.2012.03.029 | |
dc.relation.references | Werner L, Apple DJ, Izak AM, Pandey SK, Trivedi RH, Macky TA. Phakic anterior chamber intraocular lenses. Int Ophthalmol Clin. 2001;41(3):133–52. | |
dc.relation.references | Espandar L, Meyer JJ, Moshirfar M. Phakic intraocular lenses. Curr Opin Ophthalmol [Internet]. 2008 Jul [cited 2018 Apr 22];19(4):349–56. Available from: https://insights.ovid.com/crossref?an=00055735-200807000-00014 | |
dc.relation.references | Güell JL, Morral M, Gris O, Gaytan J, Sisquella M, Manero F. Five-Year Follow-up of 399 Phakic Artisan-Verisyse Implantation for Myopia, Hyperopia, and/or Astigmatism. Ophthalmology. 2008;115(6):1002–12. | |
dc.relation.references | Güell JL, Vázquez M, Malecaze F, Manero F, Gris O, Velasco F, et al. Artisan toric phakic intraocular lens for the correction of high astigmatism. Am J Ophthalmol. 2003;136(3):442–7. | |
dc.relation.references | Shajari M, Scheffel M, Koss MJ, Kohnen T. Dependency of endothelial cell loss on anterior chamber depth within first 4 years after implantation of iris-supported phakic intraocular lenses to treat high myopia. J Cataract Refract Surg [Internet]. 2016;42(11):1562–9. Available from: http://dx.doi.org/10.1016/j.jcrs.2016.08.027 | |
dc.relation.references | Ramírez VG, Hernández AT. Defectos refractivos y su corrección quirúrgica. Rev Médicas Uis. 2010;22(2). | |
dc.relation.references | Nelson L, Hodge D, Bourne W. Central corneal endothelial cell changes over a ten-year period. Am J Ophthalmol [Internet]. 1997;124(2):273–4. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002939414708104 | |
dc.relation.references | Menezo JL, Peris-Martínez C, Cisneros AL, Martínez-Costa R. Phakic intraocular lenses to correct high myopia: Adatomed, Staar, and Artisan. J Cataract Refract Surg. 2004;30(1):33–44. | |
dc.relation.references | Jonker SMR, Berendschot TTJM, Ronden AE, Saelens IEY, Bauer NJC, Nuijts RMMA. Long-Term Endothelial Cell Loss in Patients with Artisan Myopia and Artisan Toric Phakic Intraocular Lenses. 5- and 10-Year Results. Ophthalmology [Internet]. 2017;(June 2016):1–9. Available from: http://dx.doi.org/10.1016/j.ophtha.2017.08.011 | |
dc.relation.references | Tahzib NG, Nuijts RM, Wu WY, Budo CJ. Long-term Study of Artisan Phakic Intraocular Lens Implantation for the Correction of Moderate to High Myopia. Ten-Year Follow-up Results. Ophthalmology. 2007;114(6):1133–42. | |
dc.relation.references | Doors M, Cals DWJK, Berendschot TTJM, de Brabander J, Hendrikse F, Webers CAB, et al. Influence of anterior chamber morphometrics on endothelial cell changes after phakic intraocular lens implantation. J Cataract Refract Surg. 2008;34(12):2110–8. | |
dc.relation.references | Yuan X, Ping HZ, Hong WC, Yin D, Ting Z. Five-year follow-up after anterior iris-fixated intraocular lens implantation in phakic eyes to correct high myopia. Eye [Internet]. 2012;26(2):321–6. Available from: http://dx.doi.org/10.1038/eye.2011.292 | |
dc.relation.references | Budo C, Hessloehl JC, Izak M, Luyten GP., Menezo JL, Sener BA, et al. Multicenter study of the Artisan phakic intraocular lens. J Cataract Refract Surg [Internet]. 2000 Aug [cited 2018 Apr 15];26(8):1163–71. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0886335000005459 | |
dc.relation.references | Balakrishnan SA. Complications of Phakic Intraocular Lenses. 2016;56(2):161–8. | |
dc.relation.references | MacRae S, Holladay JT, Hilmantel G, Calogero D, Masket S, Stark W, et al. Special Report: American Academy of Ophthalmology Task Force Recommendations for Specular Microscopy for Phakic Intraocular Lenses. Ophthalmology [Internet]. 2017;124(1):141–2. Available from: http://dx.doi.org/10.1016/j.ophtha.2016.09.034 | |
dc.relation.references | Whikehart DR, Parikh CH, Vaughn A V, Mishler K, Edelhauser HF. Evidence suggesting the existence of stem cells for the human corneal endothelium. Mol Vis. 2005;11(January):816–24. | |
dc.relation.references | Amann J, Holley GP, Lee SB, Edelhauser HF. Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am J Ophthalmol. 2003;135(5):584–90. | |
dc.relation.references | Moshirfar M, Imbornoni LM, Ostler EM, Muthappan V. Incidence rate and occurrence of visually significant cataract formation and corneal decompensation after implantation of Verisyse/Artisan phakic intraocular lens. Clin Ophthalmol. 2014;8:711–6. | |
dc.relation.references | Kim M, Kim JK, Lee HK. Corneal endothelial decompensation after iris-claw phakic intraocular lens implantation. J Cataract Refract Surg. 2008;34(3):517–9. | |
dc.relation.references | Sayman Muslubas IB, Kandemir B, Aydin Oral AY, Kugu S, Dastan M. Long-term vision-threatening complications of phakic intraocular lens implantation for high myopia. Int J Ophthalmol [Internet]. 2014;7(2):376–80. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003099/pdf/ijo-07-02-376.pdf | |
dc.relation.references | Sikder S, Patel V, Holz HA, Mifflin MD, Davis S, Moshirfar M. Management of corneal endothelial decompensation caused by iris-fixated phakic intraocular lenses with descemet stripping automated endothelial keratoplasty. Cornea. 2011;30(9):1045–7. | |
dc.relation.references | van Eijden R, de Vries NE, Cruysberg LPJ, Webers CA, Berenschot T, Nuijts RMMA. Case of late-onset corneal decompensation after iris-fixated phakic intraocular lens implantation. J Cataract Refract Surg [Internet]. 2009;35(4):774–7. Available from: http://dx.doi.org/10.1016/j.jcrs.2008.09.032 | |
dc.relation.references | Alió JL, Toffaha BT, Peña-Garcia P, Sádaba LM, Barraquer RI. Phakic Intraocular Lens Explantation: Causes in 240 Cases. J Refract Surg [Internet]. 2015;31(1):30–5. Available from: http://www.healio.com/doiresolver?doi=10.3928/1081597X-20141202-01 | |
dc.contributor.cvlac | Tello Hernández, Alejandro [0001009125] | * |
dc.contributor.googlescholar | Tello Hernández, Alejandro [puxZHKYAAAAJ] | * |
dc.contributor.orcid | Galvis Ramírez, Virgilio [0000-0003-4587-5364] | spa |
dc.contributor.scopus | Tello Hernández, Alejandro [6603664598] | * |
dc.subject.lemb | Anormalidades de los ojos | spa |
dc.subject.lemb | Lentes fáquicos | spa |
dc.subject.lemb | Síndrome endotelial Iridocorneal | spa |
dc.subject.lemb | Medicina | spa |
dc.subject.lemb | Oftalmología | spa |
dc.subject.lemb | Investigaciones | spa |
dc.subject.lemb | Lentes oftálmicos | spa |
dc.subject.lemb | Cornea | spa |
dc.description.abstractenglish | The implantation of phakic lenses such as the Artisan lens is one of the surgical alternatives to improve visual acuity in patients for whom correction by means of Excimer Laser procedures is not indicated, such as: patients with high refractive errors (myopia, hyperopia and astigmatism), thin, very curved, or very flat corneas. The number of patients who have been implanted with the Artisan lens (iris-supporting phakic lens) has increased progressively in the last decade, but there are few studies that determine long-term outcomes (5 years or more). more) in terms of refractive results and possible late postoperative complications (including corneal endothelial loss). Endothelial cells are in charge, through their metabolic pumps, of maintaining the cornea in a stable hydration state so that the percentage of light scattering is minimal and the corneal tissue has the required transparency(1,2). The density of these endothelial cells is thus critical for this function. The corneal endothelium in humans is a tissue that almost totally lacks mitotic activity in vivo(3), therefore any type of intraocular surgical procedure implies some type of endothelial trauma, with a possible decrease in its population. Therefore, it is important to estimate the percentage of endothelial cell loss after implantation of iris support phakic lenses, which added to the approximate normal percentage loss secondary to corneal aging, would give us the total loss of endothelial cells. This percentage loss is expected to be an indicator of the long-term safety of the procedure. The aim of our study was to evaluate the safety and efficacy of the phakic Artisan lens implant, and to study in detail its safety with respect to postoperative corneal endothelial loss. Being a young population and with a great possibility of keeping the lens implanted for a longer time (4 or more decades), it is important to determine in the long term how much loss of endothelial cells can occur and thus improve the inclusion criteria. for patients who are possible candidates for the implant. | |
dc.type.redcol | http://purl.org/redcol/resource_type/TM | |
dc.rights.creativecommons | Atribución-NoComercial-SinDerivadas 2.5 Colombia | * |
dc.coverage.campus | UNAB Campus Bucaramanga | spa |
dc.description.learningmodality | Modalidad Presencial | spa |