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dc.contributor.advisorSossa Melo, Claudia Lucíaspa
dc.contributor.advisorOchoa Vera, Miguel Enriquespa
dc.contributor.authorOrtiz Becerra, Mayra Lizbethspa
dc.date.accessioned2020-06-26T19:59:56Z
dc.date.available2020-06-26T19:59:56Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12749/1747
dc.description.abstractMétodos: Mediante un estudio descriptivo analítico tipo corte transversal, se evaluó la calidad de vida relacionada con la salud (CVRS) en 56 pacientes en la FOSCAL, mediante la aplicación del cuestionario Hemolatin QoL. Resultados: Estudio descriptivo, corte transversal, 56 pacientes, 89,29% con diagnóstico de Hemofilia tipo A, y 10,71% de Hemofilia tipo B. En términos de severidad, el 60,71% con hemofilia severa, 21,43% con hemofilia moderada y 17,86% con hemofilia leve. El Índice de calidad de vida promedio encontrado en nuestros pacientes Hemofílicos de forma global fue de 71,08 puntos, equivalente en promedio al 60 – 70%, lo que engloba a los pacientes en regular y mejorable calidad de vida, la mayor afectación observada en condiciones del entorno y salud mental. Los Hemofílicos severos y moderados tienen mayor compromiso en el índice de calidad de vida (62,60% y 64,66%), respectivamente en comparación con los Hemofílicos leves (78,15%) con (p=<0,01 y p=0,02 respectivamente). En cuanto a sangrado en los últimos 12 meses, presencia de complicaciones como positividad de inhibidores, coinfección por VIH, Hepatitis C, Artropatía hemofílica no se encontraron diferencias significativas que influyeran en la calidad de vida los individuos. La mayoría de los pacientes se encontraban recibiendo manejo actual con profilaxis, sin embargo no se encontraron diferencias estadísticamente significativas con los pacientes que recibían factor a demanda, excepto para la dimensión de salud mental, presentado menor afectación para los que se encuentran con factor a demanda con una (p 0,02). En cuanto al nivel de actividad física medida con la escala GPAQ encontramos que los pacientes que tenían un nivel de actividad física alta tenían un mayor índice de CV 68,90% (IC 62,57% –75,2%) con respecto a lo que tenían un nivel de actividad baja; siendo esta diferencia significativa con una (p=0,03). Se encontró una asociación con una muy mala calidad de vida en el dominio de funcionamiento emocional con los pacientes que presentaban Baja densidad mineral ósea para la edad con una RP de 4,4 con (IC 1,05- 18,31) con una p de 0,04.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleCalidad de vida de pacientes adultos con hemofilia del nororiente colombiano, proyecto anidado al estudio “baja densidad mineral ósea y osteoporosis en pacientes con hemofilia"spa
dc.title.translatedQuality of life of adult patients with hemophilia from the colombian northeast, project nested in the study "low bone mineral density and osteoporosis in patients with hemophiliaeng
dc.degree.nameEspecialista en Medicina Internaspa
dc.coverageBucaramanga (Santander, Colombia)spa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.rights.localAbierto (Texto Completo)spa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.programEspecialización en Medicina Internaspa
dc.description.degreelevelEspecializaciónspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.localTesisspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.subject.keywordsQuality of lifeeng
dc.subject.keywordsHemophiliaeng
dc.subject.keywordsBone mineral densityeng
dc.subject.keywordsOsteoporosiseng
dc.subject.keywordsMedicineeng
dc.subject.keywordsInternal medicineeng
dc.subject.keywordsInvestigationseng
dc.subject.keywordsComplicationseng
dc.subject.keywordsPatientseng
dc.subject.keywordsPrevention and controleng
dc.subject.keywordsSymptomseng
dc.subject.keywordsExercise physicaleng
dc.subject.keywordsHemophilic patientseng
dc.subject.keywordsRisk of fractureseng
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.relation.referencesOrtiz Becerra, Mayra Lizbeth (2017). Calidad de vida de pacientes adultos con hemofilia del Nororiente Colombiano, proyecto anidado al estudio “Baja densidad mineral ósea y osteoporosis en pacientes con Hemofilia. Bucaramanga (Santander, Colombia) : Universidad Autónoma de Bucaramanga UNABspa
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dc.relation.references19. Remor E. Psychometric field study of the HemoLatin-QoL, evidence for 297 adult patients living with hemophilia in Latin American countries. Haemophilia 2008; 14 (Suppl. 2), 152. [abstract]spa
dc.relation.references20. Remor, E. Quality of life in hemophilia. In: E.C. Rodríguez-Merchán & L. Valentino. (Eds.) Current and future issues in hemophilia care. Oxford, UK: Wiley-Blackwell, 2011. doi: 10.1002/9781119979401.ch11spa
dc.relation.references21. Remor E. Quality of life and symptom assessment in hematological patients. Bleeding disorders. Hemophilia.. In: A. Novik; S. Salek; T. Ionova. (Org.). Patient-Reported Outcomes in Hematology (pp. 90-98). 1st ed. Genoa: Forum Service Editore, 2012. [LINK]spa
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dc.relation.references27. Gringeri, A. (2003). Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group. Blood, 102(7), pp.2358-2363.spa
dc.relation.references28. Plug, I., Peters, M., Mauser-Bunschoten, E., de Goede-Bolder, A., Heijnen, L., Smit, C., Willemse, J., Rosendaal, F. and van der Bom, J. (2007). Social participation of patients with hemophilia in the Netherlands. Blood, 111(4), pp.1811-1815.spa
dc.relation.references29. VON MACKENSEN, S. (2007). Quality of life and sports activities in patients with haemophilia. Haemophilia, 13(s2), pp.38-43.spa
dc.relation.references30. KHAWAJI, M., ASTERMARK, J., VON MACKENSEN, S., ÅKESSON, K. and BERNTORP, E. (2010). Bone density and health-related quality of life in adult patients with severe haemophilia. Haemophilia, 17(2), pp.304-311spa
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000898465;https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001425704*
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001512540*
dc.contributor.orcidhttps://orcid.org/0000-0002-4552-3388*
dc.contributor.scopushttps://www.scopus.com/authid/detail.uri?authorId=36987156500;https://www.scopus.com/authid/detail.uri?authorId=57203553484*
dc.contributor.researchgatehttps://www.researchgate.net/profile/Miguel_Ochoa7;https://www.researchgate.net/profile/Claudia_Sossa?_sg=BvRoh6IvojFf2p-POYF__s50hoM8A_BUZv09EbDIIEubX8HzSQD8c55b5wN2DjEMJzlDAXO3X74Ci8Q*
dc.subject.lembCalidad de vidaspa
dc.subject.lembHemofiliaspa
dc.subject.lembDensidad mineral óseaspa
dc.subject.lembOsteoporosisspa
dc.subject.lembMedicinaspa
dc.subject.lembMedicina internaspa
dc.subject.lembInvestigacionesspa
dc.subject.lembComplicacionesspa
dc.subject.lembPacientesspa
dc.subject.lembPrevención y controlspa
dc.description.abstractenglishMethods: Through a cross-sectional analytical descriptive study, evaluated the Health-related Quality of Life (HRQoL) in 56 patients in the FOSCAL, by applying the Hemolatin QoL questionnaire. Results: Descriptive study, cross section, 56 patients, 89.29% with a diagnosis of Hemophilia type A, and 10.71% Hemophilia type B. In terms of severity, the 60.71% with severe hemophilia, 21.43% with moderate hemophilia, and 17.86% with mild hemophilia. The average quality of life index found in our Hemophiliac patients overall was 71.08 points, equivalent in average 60 - 70%, which includes patients in regular and improvable quality of life, the greatest damage observed in environmental and health conditions mental. Severe and moderate hemophiliacs have a greater commitment in the quality of life index (62.60% and 64.66%), respectively compared with mild hemophiliacs (78.15%) with (p = <0.01 and p = 0.02 respectively). In regarding bleeding in the last 12 months, presence of complications such as inhibitor positivity, HIV co-infection, Hepatitis C, Hemophilic arthropathy no significant differences were found that influenced the quality of life individuals. Most of the patients were receiving current management with prophylaxis, however no statistically differences were found significant with patients receiving factor on demand, except for mental health dimension, presenting less affectation for those who find a demand factor with a (p 0.02). Regarding the level of activity physical measurement with the GPAQ scale, we found that patients who had a high level of physical activity had a higher CV index 68.90% (CI 62.57% - 75.2%) with respect to those who had a low activity level; being this significant difference with one (p = 0.03). An association was found with a very poor quality of life in the domain of emotional functioning with patients who had low bone mineral density for age with a PR of 4.4 with (CI 1.05-18.31) with a p of 0.04. Conclusions: In the present study, the quality of life related to health with the Hemolatin QoL questionnaire in patients diagnosed with Foscal hemophilia, we show that the severity of hemophilia is related to the probability of having a regular and poor quality of life, with greater impact in the domains of environmental conditions and mental health. Patients who had a high level of physical activity measured by questionnaire GPAQ had a higher CV index with respect to what they had a level of low activity. Another important finding in our study was related to low bone mineral density for age detected in hemophilic patients associated with a higher risk of fractures, with a low quality of life index compared to those with normal BMD. In summary, the severity of hemophilia was shown to be a factor associated with a higher frequency of deterioration of quality of life, independently, and the BMI with CV protective factor according to multivariate analysis.eng
dc.subject.proposalSíntomas
dc.subject.proposalActividad física
dc.subject.proposalPacientes hemofílicos
dc.subject.proposalRiesgo de fracturas
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*


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Atribución-NoComercial-SinDerivadas 2.5 Colombia
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