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dc.contributor.advisorHerrera Galindo, Víctor Mauricio
dc.contributor.authorVargas Ordóñez, Jhon Edgar
dc.date.accessioned2020-06-26T19:59:52Z
dc.date.available2020-06-26T19:59:52Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.12749/1728
dc.description.abstractObjetivo. Evaluar la asociación entre patrones de sueño y el cambio en la presión arterial (PA) e incidencia de hipertensión arterial en el contexto de la cohorte CHICAMOCHA. Métodos. El presente corresponde al análisis secundario del estudio de cohorte prospectiva CHICAMOCHA (Cardiovascular Health and Collaboration to Assess the Markers and Outcomes in Chagas disease), conducido en adultos jóvenes, seronegativos para infecciones transmisibles por vía transfusional y asintomáticos para enfermedad cardiovascular. Se consideró como la visita de referencia a la primera de seguimiento de la cohorte (2003-2006) en la que se administró un cuestionario de sueño (incluyendo aspectos del nórdico y Pittsburgh) y se realizaron mediciones antropométricas y de PA. Los participantes fueron seguidos después de una mediana de 10 años para repetir mediciones de PA y determinar la incidencia de hipertensión arterial definida como PA sistólica/diastólica ≥140/90 mmHg o tratamiento antihipertensivo. Se emplearon métodos de regresión lineal y logística múltiple para estimar las asociaciones de interés, ajustando por covariables. Resultados. Evaluamos 705 participantes (edad media=39.6 años; 64% hombres; 75% estrato socioeconómico 1-3) que asistieron tanto a la primera como la segunda visita de seguimiento después de 9.5 años (rango intercuartílico: 9.1 - 9.9 años). Los hallazgos más frecuentes con relación al sueño fueron el despertar nocturno (63.3%), el ronquido (60.7%) y problemas para conciliar el sueño (22.9%). La incidencia de hipertensión arterial fue 15.2% (IC95%: 12.6 – 18.0) hallándose que una duración entre 7.5 – 8.0 horas/día se asociaba al menor riesgo de desarrollar esta condición. Entre los atributos del sueño, solo el reporte de ronquido se asoció independientemente a un cambio en la presión arterial sistólica, pero no diastólica, de 2.2 mmHg (IC95%: 0.28, 4.12). No se evidenció interacción entre adiposidad y atributos del sueño. Conclusión. El auto-reporte de ronquido está asociado a incrementos independientes y estadísticamente significativos de la presión arterial sistólica mientras que una duración promedio del sueño principal entre 7.5 – 8.0 horas/día se asocia al menor riesgo de hipertensión arterial.spa
dc.description.tableofcontents1 DESCRIPCIÓN DEL PROYECTO ...................................................................... 7 1.1 PLANTEAMIENTO Y JUSTIFICACIÓN DEL PROBLEMA ............................... 7 2 MARCO TEÓRICO Y ESTADO DEL ARTE ....................................................... 8 3 OBJETIVOS ..................................................................................................... 12 3.1 OBJETIVO GENERAL ................................................................................... 12 3.2 OBJETIVOS ESPECÍFICOS .......................................................................... 12 4 METODOLOGÍA PROPUESTA ........................................................................ 13 4.1 DISEÑO ......................................................................................................... 13 4.2 UNIVERSO .................................................................................................... 13 4.3 POBLACIÓN OBJETO ................................................................................... 13 4.4 MUESTRA/MUESTREO ................................................................................ 13 4.5 CRITERIOS DE INCLUSIÓN Y EXCLUSIÓN ................................................ 13 4.6 VARIABLES ................................................................................................... 14 4.7 OBTENCIÓN DE LA INFORMACIÓN ............................................................ 14 4.8 PLAN DE ANÁLISIS ESTADÍSTICO .............................................................. 15 4.9 CONSIDERACIONES ÉTICAS ...................................................................... 16 5 RESULTADOS ................................................................................................. 17 6 DISCUSIÓN...................................................................................................... 19 7 CONCLUSIÓN .................................................................................................. 21 8 BIBLIOGRAFÍA ................................................................................................. 22
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dc.language.isospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleDeterminación de la asociación entre patrones del sueño y el cambio de la presión arterial en adultos de la población general: resultados de la cohorte Chicamochaspa
dc.title.translatedDetermination of the association between sleep patterns and the change in blood pressure in adults of the general population: results of the Chicamocha cohorteng
dc.degree.nameEspecialista en Medicina Interna
dc.coverageFloridablanca (Santander, Colombia)
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNAB
dc.rights.localAbierto (Texto Completo)spa
dc.publisher.facultyFacultad Ciencias de la Salud
dc.publisher.programEspecialización en Medicina Interna
dc.description.degreelevelEspecialización
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.localTesisspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.subject.keywordsBlood pressure
dc.subject.keywordsHigh blood pressure
dc.subject.keywordsAdiposity
dc.subject.keywordsDream
dc.subject.keywordsMedicine
dc.subject.keywordsInternal medicine
dc.subject.keywordsInvestigations
dc.subject.keywordsComplications
dc.subject.keywordsPatients
dc.subject.keywordsPrevention and control
dc.subject.keywordsDream architecture
dc.subject.keywordsObstructive sleep apnea syndrome (OSAS)
dc.subject.keywordsCardiovascular disease
dc.subject.keywordsRisk of hypertensive disease
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponamereponame:Repositorio Institucional UNAB
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
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dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000068020
dc.contributor.googlescholarhttps://scholar.google.es/citations?hl=es&user=ay0xprEAAAAJ
dc.contributor.orcidhttps://orcid.org/0000-0002-6295-1640
dc.contributor.orcidhttps://orcid.org/0000-0002-8939-6771
dc.contributor.scopushttps://www.scopus.com/authid/detail.uri?authorId=55402953400
dc.subject.lembPresión arterialspa
dc.subject.lembHipertensión arterialspa
dc.subject.lembAdiposidadspa
dc.subject.lembSueñospa
dc.subject.lembMedicinaspa
dc.subject.lembMedicina internaspa
dc.subject.lembInvestigacionesspa
dc.subject.lembComplicacionesspa
dc.subject.lembPacientesspa
dc.subject.lembPrevención y controlspa
dc.description.abstractenglishObjective. To evaluate the association between sleep patterns and the change in blood pressure (BP) and incidence of arterial hypertension in the context of the CHICAMOCHA cohort. Methods. This corresponds to the secondary analysis of the prospective cohort study CHICAMOCHA (Cardiovascular Health and Collaboration to Assess the Markers and Outcomes in Chagas disease), conducted in young adults, seronegative for transfusionally transmitted infections and asymptomatic for cardiovascular disease. The first follow-up visit of the cohort (2003-2006) was considered as the reference visit, in which a sleep questionnaire was administered (including aspects of Nordic and Pittsburgh) and anthropometric and BP measurements were performed. Participants were followed up after a median of 10 years to repeat BP measurements and determine the incidence of arterial hypertension defined as systolic / diastolic BP ≥140 / 90 mmHg or antihypertensive treatment. Linear regression and multiple logistic methods were used to estimate the associations of interest, adjusting for covariates. Results. We evaluated 705 participants (mean age = 39.6 years; 64% men; 75% socioeconomic stratum 1-3) who attended both the first and the second follow-up visit after 9.5 years (interquartile range: 9.1 - 9.9 years). The most frequent findings in relation to sleep were night waking (63.3%), snoring (60.7%) and problems falling asleep (22.9%). The incidence of arterial hypertension was 15.2% (95% CI: 12.6 - 18.0), finding that a duration between 7.5 - 8.0 hours / day was associated with a lower risk of developing this condition. Among the sleep attributes, only the snoring report was independently associated with a change in systolic, but not diastolic, blood pressure of 2.2 mmHg (95% CI: 0.28, 4.12). There was no evidence of interaction between adiposity and sleep attributes. Conclusion. Self-reported snoring is associated with independent and statistically significant increases in systolic blood pressure, while an average duration of main sleep between 7.5 - 8.0 hours / day is associated with a lower risk of arterial hypertension.eng
dc.subject.proposalArquitectura del sueño
dc.subject.proposalSíndrome de apnea obstructiva del sueño (SAOS)
dc.subject.proposalEnfermedad cardiovascular
dc.subject.proposalRiesgo de enfermedad hipertensiva
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*


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