dc.contributor.advisor | Tello Hernández, Alejandro | |
dc.contributor.advisor | Camacho López, Paul Anthony | |
dc.contributor.author | Viteri Solórzano, Eduardo Javier | |
dc.coverage.spatial | Santander, (Colombia) | spa |
dc.date.accessioned | 2021-08-23T21:58:25Z | |
dc.date.available | 2021-08-23T21:58:25Z | |
dc.date.issued | 2020-05-28 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12749/13966 | |
dc.description.abstract | La enfermedad cardiovascular es una de las principales causas de morbimortalidad a nivel global
y en Colombia. Actualmente existen diversos métodos para identificar el riesgo cardiovascular a
nivel individual que permiten guiar políticas públicas y decisiones clínicas. Sin embargo los
métodos no son perfectos y pueden beneficiarse de información adicional para mejorar sus
predicciones. Nuevas tecnologías en análisis de imagen de exámenes oftalmológicos actualmente
disponibles como la tomografía por coherencia óptica (OCT) permiten un análisis cuantitativo de
la microvascularización retiniana. Debido diversos reportes en la literatura que asocian cambios
en los plexos vasculares retinianos con presencia o desenlaces de enfermedad cardiovascular se
plantea un estudio para analizar si los datos objetivos y cuantificables que ofrece el OCT con
angiografía se asocian con otros marcadores individuales o puntuaciones globales de riesgo
cardiovascular ya establecidos y que se estudian actualmente en cohortes dentro de la institución.
Este análisis observacional realizado por primera vez en nuestro medio busca explorar la
existencia de posibles biomarcadores retinianos que brinden información adicionalsobre el riesgo
cardiovascular y/o permitan una referencia temprana a servicios especializados. | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | * |
dc.title | Características de la microvascularización retiniana y marcadores de riesgo cardiovascular | spa |
dc.title.translated | Characteristics of retinal microvascularization and cardiovascular risk markers | spa |
dc.degree.name | Especialista en Oftalmología | spa |
dc.publisher.grantor | Universidad Autónoma de Bucaramanga UNAB | spa |
dc.rights.local | Abierto (Texto Completo) | spa |
dc.publisher.faculty | Facultad Ciencias de la Salud | spa |
dc.publisher.program | Especialización en Oftalmología | spa |
dc.description.degreelevel | Especialización | spa |
dc.type.driver | info:eu-repo/semantics/masterThesis | |
dc.type.local | Tesis | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | |
dc.subject.keywords | Medical sciences | spa |
dc.subject.keywords | Health sciences | spa |
dc.subject.keywords | Ophthalmology | spa |
dc.subject.keywords | Retinal microvascularization | spa |
dc.subject.keywords | Cardiovascular disease | spa |
dc.subject.keywords | Blood circulation disorders | spa |
dc.subject.keywords | Medical statistics | spa |
dc.subject.keywords | Public health | spa |
dc.subject.keywords | Retinal diseases | spa |
dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga - UNAB | spa |
dc.identifier.reponame | reponame:Repositorio Institucional UNAB | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
dc.relation.references | 1. Noncommunicable diseases country profiles 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO | spa |
dc.relation.references | 2. Goto, S. Katsuki, H. Ikui, K. Kimoto, T. Mimatsu. Pathological studies on the intracerebral and retinal arteries in cerebrovascular and non cerebrovascular diseases. Stroke, 6 (1975), pp. 263- 269 | spa |
dc.relation.references | 3. Keith NM, Wagener HP, Barker NW. Some different types of essential hypertension: their course and prognosis. Am J Med Sci 1974;268:336—45 | spa |
dc.relation.references | 4. Wong T. Retinal Microvascular abnormalities and their Relationship with Hypertension. Cardiovascular Disease and Mortality. Survey Ophtalmol 2001;46:56—80 | spa |
dc.relation.references | 5. Saari, JC. Metabolism and photochemistry in the retina. In: Moses, RA.; Hart, WM., editors. Adler's Physiology of the Eye Clinical Application. Mosby; St Louis: 1987. p. 356-373. | spa |
dc.relation.references | 6. Alder VA, Ben-Nun J, Cringle SJ. PO2 profiles and oxygen consumption in cat retina with an occluded retinal circulation. Invest Ophthalmol Vis Sci. 1990; 31:1029–1034. [PubMed: 2354908 | spa |
dc.relation.references | 7. Buttery RG, Hinrichsen CF, Weller WL, Haight JR. How thick should a retina be? A comparative study of mammalian species with and without intraretinal vasculature. Vis Res. 1991; 31:169– 18. [PubMed: 2017880] | spa |
dc.relation.references | 8. Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci. 2000; 41:1217–1228. | spa |
dc.relation.references | 9. Chan-Ling, T. Blood–Brain Barriers. Wiley-VCH Verlag GmbH & Co; KgaA: 2006. The blood retinal interface: similarities and contrasts with the blood-brain interface; p. 701-724. | spa |
dc.relation.references | 10. Hollander H, Makarov F, Dreher Z, Van Driel D, Chan-Ling T, Stone J. Structure of the macroglia of the retina: the sharing and division of labour between astrocytes and Muller cells. J Comp Neurol. 1991; 313:587–603 | spa |
dc.relation.references | 11. Keeler CR. The Ophthalmoscope in the Lifetime of Hermann von Helmholtz. Arch Ophthalmol. 2002;120(2):194–201. doi:10.1001/archopht.120.2.194 | spa |
dc.relation.references | 12. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178– 1181 | spa |
dc.relation.references | 13. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27:45–88 | spa |
dc.relation.references | 14. Campbell, J. P. et al. Detailed Vascular Anatomy of the Human Retina by Projection- Resolved Optical Coherence Tomography Angiography. Sci. Rep. 7, 42201. | spa |
dc.relation.references | 15. Tan, P. E. Z. et al. Quantitative Confocal Imaging of the Retinal Microvasculature in the Human Retina. Invest. Ophthalmol. Vis. Sci. 53, 5728–9 (2012). | spa |
dc.relation.references | 16. GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980e2016: a systematic analysis for the Global Burden of Disease Study 2016.Lancet 2017;390:1151–210 | spa |
dc.relation.references | 17. K.N. Karmali et al. “Risk scoring for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2017;3:Cd006887. | spa |
dc.relation.references | 18. Piepoli MF, Hoes AW, Agewall S, et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts), developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 2016; 37:2315–81 | spa |
dc.relation.references | 19. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63:2889–934. | spa |
dc.relation.references | 20. World Health Organization. WHO Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Cardiovascular Risk. Geneva, Switzerland: World Health Organization; 2007 | spa |
dc.relation.references | 21. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (May 1998). "Prediction of coronary heart disease using risk factor categories". Circulation. 97 (18): 1837–47 | spa |
dc.relation.references | 22. Mahmood, Levy; Vasan, Wang (2013). "The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective" Lancet. 383 (9921): 999–1008 | spa |
dc.relation.references | 23. P Brindle, A McConnachie, M Upton, et al “The accuracy of the Framingham risk-score in different socioeconomic groups: a prospective study | spa |
dc.relation.references | 24. Cortes-Bergoderi M, Thomas RJ, Albuquerque FN, Batsis JA, Burdiat G, Perez-Terzic C, et al. Validity of cardiovascular risk prediction models in Latin America and among Hispanics in the United States of America: a systematic review. Rev Panam Salud Publica. 2012;32(2):131–9. | spa |
dc.relation.references | 25. Rodrigo M. Carrillo-Larco et al. Cardiovascular Disease Prognostic Models in Latin America and the Caribbean A Systematic Review GLOBAL HEART, VOL. 14, NO. 1, 2019 81 March 2019: 81-93 | spa |
dc.relation.references | 26. Muñoz OM, García AA, Fernández-Ávila D, Higuera A, Ruiz AJ, Ascher P. Guía de práctica clínica para la prevención, detección temprana, diagnóstico, tratamiento y seguimiento de las dislipidemias: evaluación del riesgo cardiovascular. Rev Colomb Cardiol. 2015;22:263 | spa |
dc.relation.references | 27. Muñoz OM et al. Concordancia entre los modelos de SCORE y Framingham y las ecuaciones AHA/ACC como evaluadores de riesgo cardiovascular. Rev Colomb Cardiol. 2017;24(2):110--- 116 | spa |
dc.relation.references | 28. Bazo-alvarez JC, Quispe R, Peralta F, Poterico JA, Valle GA, Burroughs M, et al. Agreement between cardiovascular disease risk scores in resource-limited settings: evidence from 5 peruvian sites. Crit Pathways Cardiol. 2015;14:74---80. | spa |
dc.relation.references | 29. US Preventive Services Task Force, et al. “Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Task Force Recommendation Statement.” JAMA, vol. 320, no. 3, July 2018, p. 272, doi:10.1001/jama.2018.8359 | spa |
dc.relation.references | 30. Barry E, Roberts S, Oke J, et al. Efficacy and effectiveness of screen and treat policies in prevention of type 2 diabetes: systematic review and meta-analysis of screening tests and interventions. BMJ. 2017;356:i6538 | spa |
dc.relation.references | 31. Collins, Gary S; Altman, Douglas G (21 June 2012). "Predicting the 10 year risk of cardiovascular disease in the United Kingdom: independent and external validation of an updated version of QRISK2". BMJ. 344: e4181 | spa |
dc.relation.references | 32. Wong TY, Klein R, Nieto FJ, et al. Retinal microvascular abnormalities and 10-year cardiovascular mortality: population-based case-control study. Ophthalmology. 2003;110(5):933e940 | spa |
dc.relation.references | 33. McGeechan K, Liew G, Macaskill P, et al. Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis. Am J Epidemiol. 2009;170(11):1323e1332 | spa |
dc.relation.references | 34. Chew SK, Xie J, Wang JJ. Retinal arteriolar diameter and the prevalence and incidence of hypertension: a systematic review and meta-analysis of their association. Curr Hypertens Rep. 2012;14(2):144e151 | spa |
dc.relation.references | 35. Sabanayagam C, Lye WK, Klein R, et al. Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia. 2015;58(11):2476e2485 | spa |
dc.relation.references | 36. Pontikos NWS, Faes L,Kortuem K, FaslerK, Balaskas K, Keane PA. Comment on: Trends in retina specialist imaging utilization from 2012 to 2016 in the United States Medicare fee-for- service population. Am J Ophthalmol. In press. | spa |
dc.relation.references | 37. Enoch J, McDonald L, Jones L, Jones PR, Crabb DP. Evaluating whether sight is the most valued sense [published online October 3, 2019]. JAMA Ophthalmol. | spa |
dc.relation.references | 38. Robson J, Dostal I, Sheikh A, et al. The NHS Health Check in England: an evaluation of the first 4 years. BMJ Open. 2016;6:e008840 | spa |
dc.relation.references | 39. The State of the National Eye Health 2017: A Year in Review. RNIB (2018). Available at https://www.rnib.org.uk/sites/default/files/APDF%20The%20State%20of%20the%20Nation%2 0Eye%20Health %202017%20A%20Year%20in%20Review.pdf. Accessed January 5, 2020 | spa |
dc.relation.references | 40. Arnould L, Guenancia C, Azemar A, et al. The EYE-MI pilot study: a prospective acute coronary syndrome cohort evaluated with retinal optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2018;59:4299–4306. https:// doi.org/10.1167/iovs.18-24090 | spa |
dc.relation.references | 41. Carlo TE de, Chin AT, Bonini Filho MA, et al. Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography. Retina. 2015;35:2364–2370 | spa |
dc.relation.references | 42. Tang FY, Ng DS, Lam A, et al. Determinants of quantitative optical coherence tomography angiography metrics in patients with diabetes. Sci Rep. 2017;7:2575. | spa |
dc.contributor.cvlac | Tello Hernández, Alejandro [0001009125] | spa |
dc.contributor.cvlac | Camacho López, Paul Anthony [0000323578] | spa |
dc.contributor.googlescholar | Camacho López, Paul Anthony [OvqUoOAAAAAJ&hl=es&oi=ao] | spa |
dc.contributor.orcid | Tello Hernández, Alejandro [0000-0001-5081-0720] | spa |
dc.contributor.orcid | Camacho López, Paul Anthony [0000-0002-6233-9582] | spa |
dc.contributor.researchgate | Tello Hernández, Alejandro [Alejandro-Tello] | spa |
dc.subject.lemb | Oftalmología | spa |
dc.subject.lemb | Ciencias médicas | spa |
dc.subject.lemb | Trastornos de la circulación sanguínea | spa |
dc.subject.lemb | Estadísticas médicas | spa |
dc.subject.lemb | Salud pública | spa |
dc.subject.lemb | Enfermedades de la retina | spa |
dc.identifier.repourl | repourl:https://repository.unab.edu.co | spa |
dc.description.abstractenglish | Cardiovascular disease is one of the main causes of morbidity and mortality globally and in Colombia. Currently there are various methods to identify cardiovascular risk at the individual level that allow guiding public policies and clinical decisions. However the methods are not perfect and you can benefit from additional information to improve your predictions. New technologies in image analysis of ophthalmological examinations currently available such as optical coherence tomography (OCT) allow a quantitative analysis of retinal microvascularization. Due to various reports in the literature that associate changes in the retinal vascular plexuses with the presence or outcomes of cardiovascular disease, a study is proposed to analyze whether the objective and quantifiable data offered by OCT with angiography are associated with other individual markers or global risk scores cardiovascular disease already established and currently being studied in cohorts within the institution. This observational analysis carried out for the first time in our setting seeks to explore the existence of possible retinal biomarkers that provide additional information on cardiovascular risk and / or allow an early referral to specialized services.
The World Health Organization (WHO) indicates that cardiovascular disease represents 31% of all causes of death globally. In Colombia, it stands out as the main cause of death and is an important contributor to premature mortality (30-70 years), as in other low- and lower-middle-income countries. In most patients, pathophysiological processes are present long before the disease and the development of simple tests that identify them are useful to define high-risk populations in primary or secondary care. (1)
Retinal microvascularization, easily accessible with non-invasive methods, seems to share similar physiological and anatomical characteristics with cerebral and coronary microvascularization (2). The abnormalities of these retinal plexuses could therefore reflect those observed in other vascular beds that are currently recognized as key sites in the pathophysiology of cardiovascular diseases.
Optical coherence tomography angiography (OCT-A) allows objective quantification of retinal microvascularization through computerized image analysis. This new diagnostic method is an extension of the capabilities of the software in a widely diffused equipment in current ophthalmology practice. Its use allows estimating the vascular density of retinal capillary beds in an objective and numerical way, which facilitates establishing correlations with ocular or systemic pathologies. Establishing associations between characteristics of the retinal microvasculature obtained by a non- invasive examination and known cardiovascular risk factors for our population may allow ophthalmologists to identify patients at higher risk that merit preventive actions. | spa |
dc.subject.proposal | Ciencias de la salud | spa |
dc.subject.proposal | Microvascularización retiniana | spa |
dc.subject.proposal | Enfermedad cardiovascular | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/TM | |
dc.type.redcol | http://purl.org/redcol/resource_type/TM | |
dc.rights.creativecommons | Atribución-NoComercial-SinDerivadas 2.5 Colombia | * |
dc.contributor.apolounab | Camacho López, Paul Anthony [paul-anthony-camacho-lópez] | |
dc.coverage.campus | UNAB Campus Bucaramanga | spa |
dc.description.learningmodality | Modalidad Presencial | spa |
dc.contributor.linkedin | Camacho López, Paul Anthony [paulcamachomdepi] | |