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Tratamiento farmacológico antidepresivo en adultos mayores: Guía basada en síntesis de la evidencia

dc.contributor.advisorVillar Centeno, Juan Carlos
dc.contributor.advisorSantacruz, José Manuel
dc.contributor.authorPorras Angarita, Henry Alberto
dc.coverage.spatialColombiaspa
dc.date.accessioned2021-08-12T13:36:29Z
dc.date.available2021-08-12T13:36:29Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/20.500.12749/13787
dc.description.abstractLa depresión del adulto mayor es una patología con una alta prevalencia y complicaciones, en un grupo poblacional en constante crecimiento, que conlleva múltiples desafíos por la influencia de diferentes factores biopsicosociales que no están presentes en otros grupos poblacionales. Se asocia a un peor pronóstico, curso crónico, menor respuesta antidepresiva y mayor riesgo de recaída o recurrencia. El uso de fármacos antidepresivos en ancianos se ha correlacionado con efectos adversos importantes que podrían poner en riesgo la vida y que deben ser tenidos en cuenta a la hora de pautar el tratamiento. La información que actualmente existe en guías sobre el tratamiento farmacológico antidepresivo está centrada en la población general, no están basadas en evidencia o no están sintetizadas. Estas guías permiten transmitir la información de manera clara, sintetizada, y lleva a que los profesionales de la salud puedan tomar decisiones terapéuticas de manera más rápida, evitar complicaciones, prevenir un uso inapropiado de fármacos y mejorar las pautas de tratamiento en beneficio del adulto mayor.spa
dc.description.tableofcontents1. TÍTULO DEL PROYECTO 10 2. RESUMEN 10 3. DESCRIPCIÓN DEL PROYECTO 14 3.1. PLANTEAMIENTO DEL PROBLEMA DE INVESTIGACIÓN Y SU JUSTIFICACIÓN EN TÉRMINOS DE NECESIDADES Y PERTINENCIA 14 3.2. MARCO TEORICO 18 3.3. ESTADO DEL ARTE 20 3.4. OBJETIVO GENERAL 21 OBJETIVOS ESPECÍFICOS 21 3.5. METODOLOGIA PROPUESTA 21 Búsqueda de la literatura 22 Selección de los estudios 22 3.6. PREGUNTAS DE INVESTIGACIÓN 22 ¿Cuál es la eficacia y riesgo de los antidepresivos (NO ADT) para el manejo de la depresión del adulto mayor en comparación con placebo? 22 ¿La eficacia y riesgo del uso de los antidepresivos en la población adulta mayor difiere según su mecanismo de acción? 23 ¿Cuáles son los factores que influyen en la presencia de efectos adversos graves al administrar un tratamiento antidepresivo en un adulto mayor con depresión? 23 ¿Existen diferencias en el tiempo de respuesta o remisión antidepresiva entre la población adulta mayor y población adulta joven con depresión mayor? 24 ¿En pacientes adultos mayores con depresión mayor usando antidepresivos, cuales son los factores que influyen en una recaída o recurrencia de la enfermedad? 24 4. RESULTADOS 25 4.1. ¿Cuál es la eficacia y riesgo de los antidepresivos (NO ADT) para el manejo de la depresión del adulto mayor en comparación con placebo? 25 Metodología para la búsqueda de la literatura 25 Gráfica Flujograma PRISMA 28 Resultados de la búsqueda 29 4.1.3.1. Pacientes sin deterioro cognitivo 29 Respuesta y remisión antidepresiva 29 Recaída depresión en adultos mayores sin deterioro cognitivo 30 Fractura 31 Sangrado Gastrointestinal 32 Hiponatremia 33 Suicidio 34 Muerte 35 Tabla Resumen GRADE 38 Discusión 39 Recomendaciones 40 4.1.3.2. Subgrupo: Pacientes con deterioro cognitivo 45 Respuesta y remisión antidepresiva 45 Recaída 45 Efectos adversos 46 Fractura 47 Suicidio 48 Muerte 49 Tabla Resumen GRADE 51 Discusión 51 Recomendaciones 52 4.2. ¿La eficacia y riesgo del uso de los antidepresivos en la población adulta mayor difiere según su mecanismo de acción? 57 Metodología para la búsqueda de la literatura 57 Gráfica Flujograma PRISMA 58 Resultados de la búsqueda 58 4.2.3.1. Pacientes sin deterioro cognitivo 58 Respuesta y remisión antidepresiva 58 Recaída depresión en adultos mayores sin deterioro cognitivo 60 Efectos adversos 60 Fractura 61 Muerte 61 Hiponatremia 63 Sangrado Gastro intestinal 64 Tablas de resumen GRADE 66 Discusión 70 Recomendación 71 4.2.3.2. Subgrupo: Pacientes con deterioro cognitivo 71 Tabla Resumen GRADE 72 Discusión 72 Recomendaciones 73 4.3. ¿Cuáles son los factores que influyen en la presencia de efectos adversos graves al administrar un tratamiento antidepresivo en un adulto mayor con depresión? 73 Metodología para la búsqueda de la literatura 73 Gráfica Flujograma PRISMA 74 Resultados 74 Fracturas 74 Sangrado Gastrointestinal 77 Hiponatremia 78 Suicidio 79 Muerte 81 Tabla resumen GRADE 83 Discusión 83 Recomendación 85 4.4. ¿Existen diferencias en el tiempo de respuesta o remisión antidepresiva entre la población adulta mayor y población adulta joven con depresión mayor? 86 Metodología para la búsqueda de la literatura 86 Grafica flujograma PRISMA 88 Resultados de la búsqueda 88 Discusión 89 Recomendación 90 4.5. ¿En pacientes adultos mayores con depresión mayor usando antidepresivos, cuales son los factores que influyen en una recaída o recurrencia de la enfermedad? 90 Metodología para la búsqueda de la literatura 90 Grafica flujograma PRISMA 91 Resultados de la búsqueda 91 Discusión 92 Recomendación 93 5. LIMITACIONES 94 6. MODIFICACIONES AL PROTOCOLO 95 7. APÉNDICE 96 8. BIBLIOGRAFÍA 97spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleTratamiento farmacológico antidepresivo en adultos mayores: Guía basada en síntesis de la evidenciaspa
dc.typeThesiseng
dc.title.translatedAntidepressant drug treatment in older adults: Guidance based on evidence synthesisspa
dc.degree.nameMagíster en Métodos para la Producción y Aplicación de Conocimiento Científico en Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.rights.localAbierto (Texto Completo)spa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.programMaestría en Métodos para la Producción y Aplicación de Conocimiento Científico en Saludspa
dc.description.degreelevelMaestríaspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.localTesisspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsElderlyspa
dc.subject.keywordsAntidepressantsspa
dc.subject.keywordsEvidence-based guidancespa
dc.subject.keywordsDepressionspa
dc.subject.keywordsPharmacologyspa
dc.subject.keywordsPsychotropic drugsspa
dc.subject.keywordsPathologyspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2
dc.relation.referencesAgüera-Ortiz, L., Claver-Martín, M. D., Franco-Fernández, M. D., López-Álvarez, J., Martín-Carrasco, M., Ramos-García, M. I., & Sánchez-Pérez, M. (2020). Depression in the Elderly. Consensus Statement of the Spanish Psychogeriatric Association. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.00380spa
dc.relation.referencesAlhawassi, T. M., Alatawi, W., & Alwhaibi, M. (2019). Prevalence of potentially inappropriate medications use among older adults and risk factors using the 2015 American Geriatrics Society Beers criteria. BMC Geriatrics, 19(1), 154. https://doi.org/10.1186/s12877-019 1168-1spa
dc.relation.referencesAllard, P., Gram, L., Timdahl, K., Behnke, K., Hanson, M., & Søgaard, J. (2004). Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: A double-blind, randomised 6-month comparative trial with citalopram. International Journal of Geriatric Psychiatry, 19(12), 1123-1130. https://doi.org/10.1002/gps.1190spa
dc.relation.referencesAlmeida, O. P., Alfonso, H., Hankey, G. J., & Flicker, L. (2010). Depression, antidepressant use and mortality in later life: The Health In Men Study. PloS One, 5(6), e11266. https://doi.org/10.1371/journal.pone.0011266spa
dc.relation.referencesAmerican Psychological Association (APA). (2019). Clinical Practice Guideline for the Treatment of Depression Across Three Age Cohorts American Psychological Association Guideline Development Panel for the Treatment of Depressive Disordersspa
dc.relation.referencesAnglin, R., Yuan, Y., Moayyedi, P., Tse, F., Armstrong, D., & Leontiadis, G. I. (2014). Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: A systematic review and meta-analysis. The American Journal of Gastroenterology, 109(6), 811-819. https://doi.org/10.1038/ajg.2014.82spa
dc.relation.referencesArtigas, F. (2013). Serotonin receptors involved in antidepressant effects. Pharmacology & Therapeutics, 137(1), 119-131. https://doi.org/10.1016/j.pharmthera.2012.09.006spa
dc.relation.referencesAvasthi, A., & Grover, S. (2018). Clinical Practice Guidelines for Management of Depression in Elderly. Indian Journal of Psychiatry, 60(Suppl 3), S341-S362. https://doi.org/10.4103/0019-5545.224474spa
dc.relation.referencesBains, J., Birks, J., & Dening, T. (2002). Antidepressants for treating depression in dementia. The Cochrane Database of Systematic Reviews, 4, CD003944. https://doi.org/10.1002/14651858.CD003944spa
dc.relation.referencesBajbouj, M., & Danker-Hopfe, H. (2006). Maintenance treatment of depression in old age. The New England Journal of Medicine, 354(23), 2505-2506; author reply 2505-2506spa
dc.relation.referencesBakken, M. S., Engeland, A., Engesæter, L. B., Ranhoff, A. H., Hunskaar, S., & Ruths, S. (2013). Increased risk of hip fracture among older people using antidepressant drugs: Data from the Norwegian Prescription Database and the Norwegian Hip Fracture Registry. Age and Ageing, 42(4), 514-520. https://doi.org/10.1093/ageing/aft009spa
dc.relation.referencesBanerjee, S., Hellier, J., Dewey, M., Romeo, R., Ballard, C., Baldwin, R., Bentham, P., Fox, C., Holmes, C., Katona, C., Knapp, M., Lawton, C., Lindesay, J., Livingston, G., McCrae, N., Moniz-Cook, E., Murray, J., Nurock, S., Orrell, M., … Burns, A. (2011). Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double blind, placebo-controlled trial. Lancet (London, England), 378(9789), 403-411. https://doi.org/10.1016/S0140-6736(11)60830-1spa
dc.relation.referencesBarbui, C., Esposito, E., & Cipriani, A. (2009). Selective serotonin reuptake inhibitors and risk of suicide: A systematic review of observational studies. CMAJ: Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne, 180(3), 291-297. https://doi.org/10.1503/cmaj.081514spa
dc.relation.referencesBobo, W. V., Grossardt, B. R., Lapid, M. I., Leung, J. G., Stoppel, C., Takahashi, P. Y., Hoel, R. W., Chang, Z., Lachner, C., Chauhan, M., Flowers, L., Brue, S. M., Frye, M. A., St Sauver, J., Rocca, W. A., & Sutor, B. (2019). Frequency and predictors of the potential overprescribing of antidepressants in elderly residents of a geographically defined U.S. population. Pharmacology Research & Perspectives, 7(1), e00461. https://doi.org/10.1002/prp2.461spa
dc.relation.referencesBoström, G., Hörnsten, C., Brännström, J., Conradsson, M., Nordström, P., Allard, P., Gustafson, Y., & Littbrand, H. (2016). Antidepressant use and mortality in very old people. International Psychogeriatrics, 28(7), 1201-1210. https://doi.org/10.1017/S104161021600048Xspa
dc.relation.referencesBrännström, J., Lövheim, H., Gustafson, Y., & Nordström, P. (2019). Association Between Antidepressant Drug Use and Hip Fracture in Older People Before and After Treatment Initiation. JAMA Psychiatry, 76(2), 172. https://doi.org/10.1001/jamapsychiatry.2018.3679spa
dc.relation.referencesBrzezińska, A., Bourke, J., Rivera-Hernández, R., Tsolaki, M., Woźniak, J., & Kaźmierski, J. (2020). Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses. Current Alzheimer Research, 17(1), 16-28. https://doi.org/10.2174/1567205017666200217104114spa
dc.relation.referencesBy the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. (2019). American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. Journal of the American Geriatrics Society, 67(4), 674-694. https://doi.org/10.1111/jgs.15767spa
dc.relation.referencesCenso Nacional de Población y Vivienda 2018. (s. f.). Recuperado 5 de octubre de 2020, de https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y poblacion/censo-nacional-de-poblacion-y-vivenda-2018spa
dc.relation.referencesCheng, Y.-L., Hu, H.-Y., Lin, X.-H., Luo, J.-C., Peng, Y.-L., Hou, M.-C., Lin, H.-C., & Lee, F.-Y. (2015). Use of SSRI, But Not SNRI, Increased Upper and Lower Gastrointestinal Bleeding. Medicine, 94(46). https://doi.org/10.1097/MD.0000000000002022spa
dc.relation.referencesChoi, J. W., Lee, K. S., & Han, E. (2021). Suicide risk within 1 year of dementia diagnosis in older adults: A nationwide retrospective cohort study. Journal of Psychiatry & Neuroscience: JPN, 46(1), E119-E127. https://doi.org/10.1503/jpn.190219spa
dc.relation.referencesCipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. P. A., & Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet (London, England), 391(10128), 1357-1366. https://doi.org/10.1016/S0140-6736(17)32802-7spa
dc.relation.referencesCorona, G., Giuliani, C., Parenti, G., Colombo, G. L., Sforza, A., Maggi, M., Forti, G., & Peri, A. (2016). The Economic Burden of Hyponatremia: Systematic Review and Meta-Analysis. The American Journal of Medicine, 129(8), 823-835.e4. https://doi.org/10.1016/j.amjmed.2016.03.007spa
dc.relation.referencesCorona, G., Norello, D., Parenti, G., Sforza, A., Maggi, M., & Peri, A. (2018). Hyponatremia, falls and bone fractures: A systematic review and meta-analysis. Clinical Endocrinology, 89(4), 505 513. https://doi.org/10.1111/cen.13790spa
dc.relation.referencesCoupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G., & Hippisley-Cox, J. (2011). Antidepressant use and risk of adverse outcomes in older people: Population based cohort study. BMJ (Clinical Research Ed.), 343, d4551. https://doi.org/10.1136/bmj.d4551spa
dc.relation.referencesDavies, L. E., Spiers, G., Kingston, A., Todd, A., Adamson, J., & Hanratty, B. (2020). Adverse Outcomes of Polypharmacy in Older People: Systematic Review of Reviews. Journal of the 101 American Medical Directors Association, 21(2), 181-187. https://doi.org/10.1016/j.jamda.2019.10.022spa
dc.relation.referencesde Vasconcelos Cunha, U. G., Lopes Rocha, F., Avila de Melo, R., Alves Valle, E., de Souza Neto, J. J., Mendes Brega, R., Magalhães Scoralick, F., Araújo Silva, S., Martins de Oliveira, F., da Costa Júnior, A. L., Faria Alves, V. X., & Sakurai, E. (2007). A placebo-controlled double-blind randomized study of venlafaxine in the treatment of depression in dementia. Dementia and Geriatric Cognitive Disorders, 24(1), 36-41. https://doi.org/10.1159/000102570spa
dc.relation.referencesDiem, S. J., Blackwell, T. L., Stone, K. L., Cauley, J. A., Hillier, T. A., Haney, E. M., & Ensrud, K. E. (2011). Use of Antidepressant Medications and Risk of Fracture in Older Women. Calcified tissue international, 88(6), 476-484. https://doi.org/10.1007/s00223-011-9481-5spa
dc.relation.referencesDriscoll, H. C., Basinski, J., Mulsant, B. H., Butters, M. A., Dew, M. A., Houck, P. R., Mazumdar, S., Miller, M. D., Pollock, B. G., Stack, J. A., Schlernitzauer, M. A., & Reynolds, C. F. (2005). Late-onset major depression: Clinical and treatment-response variability. International Journal of Geriatric Psychiatry, 20(7), 661-667. https://doi.org/10.1002/gps.1334spa
dc.relation.referencesDu, Y., Wolf, I.-K., Busch, M. A., & Knopf, H. (2019). Associations between the use of specific psychotropic drugs and all-cause mortality among older adults in Germany: Results of the mortality follow-up of the German National Health Interview and Examination Survey 1998. PloS One, 14(1), e0210695. https://doi.org/10.1371/journal.pone.0210695spa
dc.relation.referencesDudas, R., Malouf, R., McCleery, J., & Dening, T. (2018). Antidepressants for treating depression in dementia. The Cochrane Database of Systematic Reviews, 8, CD003944. https://doi.org/10.1002/14651858.CD003944.pub2spa
dc.relation.referencesEmeny, R. T., Chang, C.-H., Skinner, J., O’Malley, A. J., Smith, J., Chakraborti, G., Rosen, C. J., & Morden, N. E. (2019). Association of Receiving Multiple, Concurrent Fracture-Associated 102 Drugs With Hip Fracture Risk. JAMA Network Open, 2(11), e1915348. https://doi.org/10.1001/jamanetworkopen.2019.15348spa
dc.relation.referencesEnache, D., Fereshtehnejad, S.-M., Kåreholt, I., Cermakova, P., Garcia-Ptacek, S., Johnell, K., Religa, D., Jelic, V., Winblad, B., Ballard, C., Aarsland, D., Fastbom, J., & Eriksdotter, M. (2016). Antidepressants and mortality risk in a dementia cohort: Data from SveDem, the Swedish Dementia Registry. Acta Psychiatrica Scandinavica, 134(5), 430-440. https://doi.org/10.1111/acps.12630spa
dc.relation.referencesEom, C.-S., Lee, H.-K., Ye, S., Park, S. M., & Cho, K.-H. (2012). Use of selective serotonin reuptake inhibitors and risk of fracture: A systematic review and meta-analysis. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 27(5), 1186-1195. https://doi.org/10.1002/jbmr.1554spa
dc.relation.referencesFabian, T. J., Amico, J. A., Kroboth, P. D., Mulsant, B. H., Corey, S. E., Begley, A. E., Bensasi, S. G., Weber, E., Dew, M. A., Reynolds, C. F., & Pollock, B. G. (2004). Paroxetine-induced hyponatremia in older adults: A 12-week prospective study. Archives of Internal Medicine, 164(3), 327-332. https://doi.org/10.1001/archinte.164.3.327spa
dc.relation.referencesFarmand, S., Lindh, J. D., Calissendorff, J., Skov, J., Falhammar, H., Nathanson, D., & Mannheimer, B. (2018). Differences in Associations of Antidepressants and Hospitalization Due to Hyponatremia. The American Journal of Medicine, 131(1), 56-63. https://doi.org/10.1016/j.amjmed.2017.07.025spa
dc.relation.referencesFergusson, D., Doucette, S., Glass, K. C., Shapiro, S., Healy, D., Hebert, P., & Hutton, B. (2005). Association between suicide attempts and selective serotonin reuptake inhibitors: Systematic review of randomised controlled trials. BMJ : British Medical Journal, 330(7488), 396spa
dc.relation.referencesFurukawa, T. A., Cipriani, A., Cowen, P. J., Leucht, S., Egger, M., & Salanti, G. (2019). Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: A systematic review and dose-response meta-analysis. The Lancet. Psychiatry, 6(7), 601-609. https://doi.org/10.1016/S2215-0366(19)30217-2spa
dc.relation.referencesGandhi, S., Shariff, S. Z., Al-Jaishi, A., Reiss, J. P., Mamdani, M. M., Hackam, D. G., Li, L., McArthur, E., Weir, M. A., & Garg, A. X. (2017). Second-Generation Antidepressants and Hyponatremia Risk: A Population-Based Cohort Study of Older Adults. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 69(1), 87-96. https://doi.org/10.1053/j.ajkd.2016.08.020spa
dc.relation.referencesGonzález Quiñones, J. C. (2017). Resumen: «Sabe Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento». Carta Comunitaria, 25(144), 24.spa
dc.relation.referencesGorwood, P., Weiller, E., Lemming, O., & Katona, C. (2007). Escitalopram prevents relapse in older patients with major depressive disorder. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 15(7), 581-593. https://doi.org/10.1097/01.JGP.0000240823.94522.4cspa
dc.relation.referencesGøtzsche, P. C., & Dinnage, O. (2020). What have antidepressants been tested for? A systematic review. The International Journal of Risk & Safety in Medicine, 31(3), 157-163. https://doi.org/10.3233/JRS-200006spa
dc.relation.referencesGrayson, L., & Thomas, A. (2013). A systematic review comparing clinical features in early age at onset and late age at onset late-life depression. Journal of Affective Disorders, 150(2), 161 170. https://doi.org/10.1016/j.jad.2013.03.021spa
dc.relation.referencesGutiérrez-Rojas, L., Porras-Segovia, A., Dunne, H., Andrade-González, N., & Cervilla, J. A. (2020). Prevalence and correlates of major depressive disorder: A systematic review. Revista Brasileira De Psiquiatria (Sao Paulo, Brazil: 1999). https://doi.org/10.1590/1516-4446 2020-0650spa
dc.relation.referencesHedna, K., Andersson Sundell, K., Hensing, G., Skoog, I., Gustavsson, S., & Waern, M. (2018). Late life suicidal behaviours among new users of antidepressants: A prospective population based study of sociodemographic and gender factors in those aged 75 and above. BMJ Open, 8(10). https://doi.org/10.1136/bmjopen-2018-022703spa
dc.relation.referencesHedna, K., Hensing, G., Skoog, I., Fastbom, J., & Waern, M. (2020). Sociodemographic and gender determinants of late-life suicide in users and non-users of antidepressants. The European Journal of Public Health, 30(5), 958-964. https://doi.org/10.1093/eurpub/ckaa114spa
dc.relation.referencesHedrick, R., Korouri, S., Tadros, E., Darwish, T., Cortez, V., Triay, D., Pasini, M., Olanisa, L., Herrera, N., Hanna, S., Kimchi, A., Hamilton, M., Danovitch, I., & IsHak, W. W. (2020). The impact of antidepressants on depressive symptom severity, quality of life, morbidity, and mortality in heart failure: A systematic review. Drugs in Context, 9. https://doi.org/10.7573/dic.2020-5-4spa
dc.relation.referencesHegeman, J. M., Kok, R. M., Mast, R. C. van der, & Giltay, E. J. (2012). Phenomenology of depression in older compared with younger adults: Meta-analysis. The British Journal of Psychiatry, 200(4), 275-281. https://doi.org/10.1192/bjp.bp.111.095950spa
dc.relation.referencesHengartner, M. P., Amendola, S., Kaminski, J. A., Kindler, S., Bschor, T., & Plöderl, M. (2020). Suicide risk with selective serotonin reuptake inhibitors and new-generation serotonergic noradrenergic antidepressants in adults: A systematic review and meta-analysis of observational studies. MedRxiv, 2020.05.11.20098178. https://doi.org/10.1101/2020.05.11.20098178spa
dc.relation.referencesHenssler, J., Kurschus, M., Franklin, J., Bschor, T., & Baethge, C. (2018). Trajectories of Acute Antidepressant Efficacy: How Long to Wait for Response? A Systematic Review and Meta 105 Analysis of Long-Term, Placebo-Controlled Acute Treatment Trials. The Journal of Clinical Psychiatry, 79(3). https://doi.org/10.4088/JCP.17r11470spa
dc.relation.referencesJeuring, H. W., Stek, M. L., Huisman, M., Oude Voshaar, R. C., Naarding, P., Collard, R. M., van der Mast, R. C., Kok, R. M., Beekman, A. T. F., & Comijs, H. C. (2018). A Six-Year Prospective Study of the Prognosis and Predictors in Patients With Late-Life Depression. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 26(9), 985-997. https://doi.org/10.1016/j.jagp.2018.05.005spa
dc.relation.referencesJiang, H.-Y., Chen, H.-Z., Hu, X.-J., Yu, Z.-H., Yang, W., Deng, M., Zhang, Y.-H., & Ruan, B. (2015). Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: A systematic review and meta-analysis. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 13(1), 42 50.e3. https://doi.org/10.1016/j.cgh.2014.06.021spa
dc.relation.referencesKasper, S., de Swart, H., & Friis Andersen, H. (2005). Escitalopram in the treatment of depressed elderly patients. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 13(10), 884-891. https://doi.org/10.1176/appi.ajgp.13.10.884spa
dc.relation.referencesKatona, C., Hansen, T., & Olsen, C. K. (2012). A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder: International Clinical Psychopharmacology, 27(4), 215-223. https://doi.org/10.1097/YIC.0b013e3283542457spa
dc.relation.referencesKhanassov, V., Hu, J., Reeves, D., & van Marwijk, H. (2018). Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: A systematic review and meta-analysis. International Journal of Geriatric Psychiatry, 33(12), 1688-1708. https://doi.org/10.1002/gps.4974spa
dc.relation.referencesKlysner, R., Bent-Hansen, J., Hansen, H. L., Lunde, M., Pleidrup, E., Poulsen, D. L., Andersen, M., & Petersen, H. E. H. (2002). Efficacy of citalopram in the prevention of recurrent depression in elderly patients: Placebo-controlled study of maintenance therapy. The British Journal of Psychiatry: The Journal of Mental Science, 181, 29-35. https://doi.org/10.1192/bjp.181.1.29spa
dc.relation.referencesKok, R. M., Nolen, W. A., & Heeren, T. J. (2012). Efficacy of treatment in older depressed patients: A systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. Journal of Affective Disorders, 141(2-3), 103-115. https://doi.org/10.1016/j.jad.2012.02.036spa
dc.relation.referencesKoKoAung, E., Cavenett, S., McArthur, A., & Aromataris, E. (2015). The association between suicidality and treatment with selective serotonin reuptake inhibitors in older people with major depression: A systematic review. JBI Database of Systematic Reviews and Implementation Reports, 13(3), 174-205. https://doi.org/10.11124/jbisrir-2015-2272spa
dc.relation.referencesKollhorst, B., Jobski, K., Krappweis, J., Schink, T., Garbe, E., & Schmedt, N. (2019). Antidepressants and the risk of death in older patients with depression: A population-based cohort study. PLOS ONE, 14(4), e0215289. https://doi.org/10.1371/journal.pone.0215289spa
dc.relation.referencesKrause, M., Gutsmiedl, K., Bighelli, I., Schneider-Thoma, J., Chaimani, A., & Leucht, S. (2019). Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 29(9), 1003-1022. https://doi.org/10.1016/j.euroneuro.2019.07.130spa
dc.relation.referencesKumar, M., Bajpai, R., Shaik, A. R., Srivastava, S., & Vohora, D. (2020). Alliance between selective serotonin reuptake inhibitors and fracture risk: An updated systematic review and meta 107 analysis. European Journal of Clinical Pharmacology, 76(10), 1373-1392. https://doi.org/10.1007/s00228-020-02893-1spa
dc.relation.referencesKuring, J. K., Mathias, J. L., & Ward, L. (2018). Prevalence of Depression, Anxiety and PTSD in People with Dementia: A Systematic Review and Meta-Analysis. Neuropsychology Review, 28(4), 393-416. https://doi.org/10.1007/s11065-018-9396-2spa
dc.relation.referencesLam, R. W., Kennedy, S. H., Grigoriadis, S., McIntyre, R. S., Milev, R., Ramasubbu, R., Parikh, S. V., Patten, S. B., & Ravindran, A. V. (2009). Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.: III. Pharmacotherapy. Journal of Affective Disorders, 117, S26-S43. https://doi.org/10.1016/j.jad.2009.06.041spa
dc.relation.referencesLanteigne, A., Sheu, Y., Stürmer, T., Pate, V., Azrael, D., Swanson, S. A., & Miller, M. (2015). Serotonin-Norepinephrine Reuptake Inhibitor and Selective Serotonin Reuptake Inhibitor Use and Risk of Fractures: A new-user cohort study among US adults aged 50 and older. CNS drugs, 29(3), 245-252. https://doi.org/10.1007/s40263-015-0231-5spa
dc.relation.referencesLeach, M. J., Pratt, N. L., & Roughead, E. E. (2017). Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case-Control Study in Australia. Drugs - Real World Outcomes, 4(2), 87-96. https://doi.org/10.1007/s40801-017-0107-8spa
dc.relation.referencesLeipzig, R. M., Cumming, R. G., & Tinetti, M. E. (1999). Drugs and falls in older people: A systematic review and meta-analysis: I. Psychotropic drugs. Journal of the American Geriatrics Society, 47(1), 30-39. https://doi.org/10.1111/j.1532-5415.1999.tb01898.xspa
dc.relation.referenceseth-Møller, K. B., Hansen, A. H., Torstensson, M., Andersen, S. E., Ødum, L., Gislasson, G., Torp Pedersen, C., & Holm, E. A. (2016). Antidepressants and the risk of hyponatremia: A Danish 108 register-based population study. BMJ Open, 6(5), e011200. https://doi.org/10.1136/bmjopen-2016-011200spa
dc.relation.referencesLi, J.-Q., Tan, L., Wang, H.-F., Tan, M.-S., Tan, L., Xu, W., Zhao, Q.-F., Wang, J., Jiang, T., & Yu, J.-T. (2016). Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: A systematic review and meta-analysis of cohort studies. Journal of Neurology, Neurosurgery, and Psychiatry, 87(5), 476-484. https://doi.org/10.1136/jnnp 2014-310095spa
dc.relation.referencesLicht-Strunk, E., van der Windt, D. A., van Marwijk, H. W., de Haan, M., & Beekman, A. T. (2007). The prognosis of depression in older patients in general practice and the community. A systematic review. Family Practice, 24(2), 168-180. https://doi.org/10.1093/fampra/cml071spa
dc.relation.referencesLivingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., Costafreda, S. G., Dias, A., Fox, N., Gitlin, L. N., Howard, R., Kales, H. C., Kivimäki, M., Larson, E. B., Ogunniyi, A., … Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396(10248), 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6spa
dc.relation.referencesLoke, Y. K., Trivedi, A. N., & Singh, S. (2007). Meta-analysis: Gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti inflammatory drugs: META-ANALYSIS: GASTROINTESTINAL BLEEDING WITH SSRIS AND NSAID. Alimentary Pharmacology & Therapeutics, 27(1), 31-40. https://doi.org/10.1111/j.1365-2036.2007.03541.xspa
dc.relation.referencesLombardi, G., Ferraro, P. M., Calvaruso, L., Naticchia, A., D’Alonzo, S., & Gambaro, G. (2019). Sodium Fluctuations and Mortality in a General Hospitalized Population. Kidney & Blood Pressure Research, 44(4), 604-614. https://doi.org/10.1159/000500916spa
dc.relation.referencesLuppa, M., Sikorski, C., Luck, T., Ehreke, L., Konnopka, A., Wiese, B., Weyerer, S., König, H.-H., & Riedel-Heller, S. G. (2012). Age- and gender-specific prevalence of depression in latest life—Systematic review and meta-analysis. Journal of Affective Disorders, 136(3), 212-221. https://doi.org/10.1016/j.jad.2010.11.033spa
dc.relation.referencesLuzecky, M. H., Burman, K. D., & Schultz, E. R. (1974). The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration. Southern Medical Journal, 67(4), 495-497. https://doi.org/10.1097/00007611-197404000-00027spa
dc.relation.referencesLyketsos, C. G., DelCampo, L., Steinberg, M., Miles, Q., Steele, C. D., Munro, C., Baker, A. S., Sheppard, J.-M. E., Frangakis, C., Brandt, J., & Rabins, P. V. (2003). Treating depression in Alzheimer disease: Efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Archives of General Psychiatry, 60(7), 737-746. https://doi.org/10.1001/archpsyc.60.7.737spa
dc.relation.referencesMahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014). Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and Biobehavioral Reviews, 38, 173-192. https://doi.org/10.1016/j.neubiorev.2013.11.009spa
dc.relation.referencesMallery, L., MacLeod, T., Allen, M., McLean-Veysey, P., Rodney-Cail, N., Bezanson, E., Steeves, B., LeBlanc, C., & Moorhouse, P. (2019). Systematic review and meta-analysis of second generation antidepressants for the treatment of older adults with depression: Questionable benefit and considerations for frailty. BMC Geriatrics, 19(1), 306. https://doi.org/10.1186/s12877-019-1327-4spa
dc.relation.referencesMannesse, C. K., Vondeling, A. M., van Marum, R. J., van Solinge, W. W., Egberts, T. C. G., & Jansen, P. A. F. (2013). Prevalence of hyponatremia on geriatric wards compared to other 110 settings over four decades: A systematic review. Ageing Research Reviews, 12(1), 165-173. https://doi.org/10.1016/j.arr.2012.04.006spa
dc.relation.referencesMinisterio de Salud y Protección Social - Colciencias. (2013). Guía de práctica clínica Detección temprana y diagnóstico del episodio depresivo y trastorno depresivo recurrente en adultos. Atención integral de los adultos con diagnóstico de episodio depresivo o trastorno depresivo recurrente. https://medicosgeneralescolombianos.com/images/Guias_2013/gpc_22prof_sal_depre.p dfspa
dc.relation.referencesMitchell, A. J., & Subramaniam, H. (2005). Prognosis of depression in old age compared to middle age: A systematic review of comparative studies. The American Journal of Psychiatry, 162(9), 1588-1601. https://doi.org/10.1176/appi.ajp.162.9.1588spa
dc.relation.referencesMottram, P., Wilson, K., & Strobl, J. (2006). Antidepressants for depressed elderly. The Cochrane Database of Systematic Reviews, 1, CD003491. https://doi.org/10.1002/14651858.CD003491.pub2spa
dc.relation.referencesMovig, K. L. L., Leufkens, H. G. M., Lenderink, A. W., & Egberts, A. C. G. (2002). Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly. European Journal of Clinical Pharmacology, 58(2), 143-148. https://doi.org/10.1007/s00228-002-0438-5spa
dc.relation.referencesMukai, Y., & Tampi, R. R. (2009). Treatment of depression in the elderly: A review of the recent literature on the efficacy of single- versus dual-action antidepressants. Clinical Therapeutics, 31(5), 945-961. https://doi.org/10.1016/j.clinthera.2009.05.016spa
dc.relation.referencesMurthy, K., Ondrey, G. J., Malkani, N., Raman, G., Hodge, M. B., Marcantonio, A. J., & Verbalis, J. G. (2019). THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocrine Practice: Official Journal of the 111 American College of Endocrinology and the American Association of Clinical Endocrinologists, 25(4), 366-378. https://doi.org/10.4158/EP-2018-0499spa
dc.relation.referencesNelson, J. C., Delucchi, K., & Schneider, L. S. (2008a). Efficacy of second generation antidepressants in late-life depression: A meta-analysis of the evidence. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 16(7), 558 567. https://doi.org/10.1097/JGP.0b013e3181693288spa
dc.relation.referencesNelson, J. C., Delucchi, K., & Schneider, L. S. (2008b). Efficacy of Second Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence. The American Journal of Geriatric Psychiatry, 16(7), 558-567. https://doi.org/10.1097/01.JGP.0000308883.64832.edspa
dc.relation.referencesNelson, J. C., & Devanand, D. P. (2011). A systematic review and meta-analysis of placebo controlled antidepressant studies in people with depression and dementia. Journal of the American Geriatrics Society, 59(4), 577-585. https://doi.org/10.1111/j.1532 5415.2011.03355.xspa
dc.relation.referencesNervenheilkunde (DGPPN), D. G. F. P., Psychotherapie Und, & Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ). (2015). S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression—Langfassung, 2. Auflage [Text/pdf]. Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN); Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). https://doi.org/10.6101/AZQ/000364spa
dc.relation.referencesOderda, L. H., Young, J. R., Asche, C. V., & Pepper, G. A. (2012). Psychotropic-related hip fractures: Meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs. The Annals of Pharmacotherapy, 46(7-8), 917-928. https://doi.org/10.1345/aph.1Q589spa
dc.relation.referencesOka, Y., Okamoto, K., Kawashita, N., Shirakuni, Y., & Takagi, T. (2014). Meta-analysis of the Risk of Upper Gastrointestinal Hemorrhage with Combination Therapy of Selective Serotonin Reuptake Inhibitors and Non-steroidal Anti-inflammatory Drugs. Biological and Pharmaceutical Bulletin, 37(6), 947-953. https://doi.org/10.1248/bpb.b13-00885spa
dc.relation.referencesO’Mahony, D., O’Sullivan, D., Byrne, S., O’Connor, M. N., Ryan, C., & Gallagher, P. (2015). STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age and Ageing, 44(2), 213-218. https://doi.org/10.1093/ageing/afu145spa
dc.relation.referencesOrgeta, V., Tabet, N., Nilforooshan, R., & Howard, R. (2017). Efficacy of Antidepressants for Depression in Alzheimer’s Disease: Systematic Review and Meta-Analysis. Journal of Alzheimer’s Disease: JAD, 58(3), 725-733. https://doi.org/10.3233/JAD-161247spa
dc.relation.referencesPeeters, C. M. M., Visser, E., Van de Ree, C. L. P., Gosens, T., Den Oudsten, B. L., & De Vries, J. (2016). Quality of life after hip fracture in the elderly: A systematic literature review. Injury, 47(7), 1369-1382. https://doi.org/10.1016/j.injury.2016.04.018spa
dc.relation.referencesPohl, P., Nordin, E., Lundquist, A., Bergström, U., & Lundin-Olsson, L. (2014). Community-dwelling older people with an injurious fall are likely to sustain new injurious falls within 5 years—A prospective long-term follow-up study. BMC Geriatrics, 14, 120. https://doi.org/10.1186/1471-2318-14-120spa
dc.relation.referencesPractice guideline for the treatment of patients with major depressive disorder, third edition Clinical Practice Guidelines. (s. f.). Guideline Central. Recuperado 12 de octubre de 2020, de https://www.guidelinecentral.com/summaries/practice-guideline-for-the-treatment of-patients-with-major-depressive-disorder-third-editionspa
dc.relation.referencesPrieto-Alhambra, D., Petri, H., Goldenberg, J. S. B., Khong, T. P., Klungel, O. H., Robinson, N. J., & de Vries, F. (2014). Excess risk of hip fractures attributable to the use of antidepressants in five European countries and the USA. Osteoporosis International: A Journal Established as 113 Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 25(3), 847-855. https://doi.org/10.1007/s00198-013-2612-2spa
dc.relation.referencesRabenda, V., Nicolet, D., Beaudart, C., Bruyère, O., & Reginster, J.-Y. (2013). Relationship between use of antidepressants and risk of fractures: A meta-analysis. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(1), 121-137. https://doi.org/10.1007/s00198-012-2015-9spa
dc.relation.referencesRajeswaran, T., Plymen, C. M., & Doherty, A. M. (2018). The effect of antidepressant medications in the management of heart failure on outcomes: Mortality, cardiovascular function and depression - a systematic review. International Journal of Psychiatry in Clinical Practice, 22(3), 164-169. https://doi.org/10.1080/13651501.2017.1401085spa
dc.relation.referencesRaskin, J., Wiltse, C. G., Dinkel, J. J., Walker, D. J., Desaiah, D., & Katona, C. (2008). Safety and tolerability of duloxetine at 60 mg once daily in elderly patients with major depressive disorder. Journal of Clinical Psychopharmacology, 28(1), 32-38. https://doi.org/10.1097/jcp.0b013e318160738espa
dc.relation.referencesReynolds, C. F., Dew, M. A., Frank, E., Begley, A. E., Miller, M. D., Cornes, C., Mazumdar, S., Perel, J. M., & Kupfer, D. J. (1998). Effects of age at onset of first lifetime episode of recurrent major depression on treatment response and illness course in elderly patients. The American Journal of Psychiatry, 155(6), 795-799. https://doi.org/10.1176/ajp.155.6.795spa
dc.relation.referencesReynolds, Charles F., Dew, M. A., Pollock, B. G., Mulsant, B. H., Frank, E., Miller, M. D., Houck, P. R., Mazumdar, S., Butters, M. A., Stack, J. A., Schlernitzauer, M. A., Whyte, E. M., Gildengers, A., Karp, J., Lenze, E., Szanto, K., Bensasi, S., & Kupfer, D. J. (2006). Maintenance treatment 114 of major depression in old age. The New England Journal of Medicine, 354(11), 1130-1138. https://doi.org/10.1056/NEJMoa052619spa
dc.relation.referencesRobinson, M., Oakes, T. M., Raskin, J., Liu, P., Shoemaker, S., & Nelson, J. C. (2014). Acute and Long-term Treatment of Late-Life Major Depressive Disorder: Duloxetine Versus Placebo. The American Journal of Geriatric Psychiatry, 22(1), 34-45. https://doi.org/10.1016/j.jagp.2013.01.019spa
dc.relation.referencesRosenberg, P. B., Drye, L. T., Martin, B. K., Frangakis, C., Mintzer, J. E., Weintraub, D., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., & Lyketsos, C. G. (2010). Sertraline for the treatment of depression in Alzheimer’s disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 18(2), 136-145. https://doi.org/10.1097/JGP.0b013e3181c796ebspa
dc.relation.referencesRyan, J., Carriere, I., Ritchie, K., Stewart, R., Toulemonde, G., Dartigues, J.-F., Tzourio, C., & Ancelin, M.-L. (2008). Late-life depression and mortality: Influence of gender and antidepressant use. The British Journal of Psychiatry: The Journal of Mental Science, 192(1), 12-18. https://doi.org/10.1192/bjp.bp.107.039164spa
dc.relation.referencesSchatzberg, A., & Roose, S. (2006). A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 14(4), 361-370. https://doi.org/10.1097/01.JGP.0000194645.70869.3bspa
dc.relation.referencesSeitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. (2011). Antidepressants for agitation and psychosis in dementia. The Cochrane Database of Systematic Reviews, 2, CD008191. https://doi.org/10.1002/14651858.CD008191.pub2spa
dc.relation.referencesSeppala, L. J., Wermelink, A. M. A. T., de Vries, M., Ploegmakers, K. J., van de Glind, E. M. M., Daams, J. G., van der Velde, N., & EUGMS task and Finish group on fall-risk-increasing 115 drugs. (2018). Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: II. Psychotropics. Journal of the American Medical Directors Association, 19(4), 371.e11 371.e17. https://doi.org/10.1016/j.jamda.2017.12.098spa
dc.relation.referencesSeyfried, L. S., Kales, H. C., Ignacio, R. V., Conwell, Y., & Valenstein, M. (2011). Predictors of suicide in patients with dementia. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 7(6), 567-573. https://doi.org/10.1016/j.jalz.2011.01.006spa
dc.relation.referencesSjöberg, L., Karlsson, B., Atti, A.-R., Skoog, I., Fratiglioni, L., & Wang, H.-X. (2017). Prevalence of depression: Comparisons of different depression definitions in population-based samples of older adults. Journal of Affective Disorders, 221, 123-131. https://doi.org/10.1016/j.jad.2017.06.011spa
dc.relation.referencesSmith, D., Dempster, C., Glanville, J., Freemantle, N., & Anderson, I. (2002). Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: A meta-analysis. The British Journal of Psychiatry: The Journal of Mental Science, 180, 396-404. https://doi.org/10.1192/bjp.180.5.396spa
dc.relation.referencesTedeschini, E., Levkovitz, Y., Iovieno, N., Ameral, V. E., Nelson, J. C., & Papakostas, G. I. (2011). Efficacy of antidepressants for late-life depression: A meta-analysis and meta-regression of placebo-controlled randomized trials. The Journal of Clinical Psychiatry, 72(12), 1660-1668. https://doi.org/10.4088/JCP.10r06531spa
dc.relation.referencesTham, A., Jonsson, U., Andersson, G., Söderlund, A., Allard, P., & Bertilsson, G. (2016a). Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder—A systematic review and a meta-analysis. Journal of Affective Disorders, 205, 1 12. https://doi.org/10.1016/j.jad.2016.06.013spa
dc.relation.referencesTham, A., Jonsson, U., Andersson, G., Söderlund, A., Allard, P., & Bertilsson, G. (2016b). Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive 116 disorder—A systematic review and a meta-analysis. Journal of Affective Disorders, 205, 1 12. https://doi.org/10.1016/j.jad.2016.06.013spa
dc.relation.referencesThompson, S., Herrmann, N., Rapoport, M. J., & Lanctôt, K. L. (2007). Efficacy and safety of antidepressants for treatment of depression in Alzheimer’s disease: A metaanalysis. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 52(4), 248-255. https://doi.org/10.1177/070674370705200407spa
dc.relation.referencesThorlund, K., Druyts, E., Wu, P., Balijepalli, C., Keohane, D., & Mills, E. (2015). Comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults: A network meta-analysis. Journal of the American Geriatrics Society, 63(5), 1002-1009. https://doi.org/10.1111/jgs.13395spa
dc.relation.referencesTorvinen-Kiiskinen, S., Tolppanen, A.-M., Koponen, M., Tanskanen, A., Tiihonen, J., Hartikainen, S., & Taipale, H. (2017). Antidepressant use and risk of hip fractures among community dwelling persons with and without Alzheimer’s disease. International Journal of Geriatric Psychiatry, 32(12), e107-e115. https://doi.org/10.1002/gps.4667spa
dc.relation.referencesUpala, S., & Sanguankeo, A. (2016). Association Between Hyponatremia, Osteoporosis, and Fracture: A Systematic Review and Meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 101(4), 1880-1886. https://doi.org/10.1210/jc.2015-4228spa
dc.relation.referencesVida, S., Des Rosiers, P., Carrier, L., & Gauthier, S. (1994). Prevalence of depression in Alzheimer’s disease and validity of Research Diagnostic Criteria. Journal of Geriatric Psychiatry and Neurology, 7(4), 238-244. https://doi.org/10.1177/089198879400700409spa
dc.relation.referencesWatt, J. A., Goodarzi, Z., Veroniki, A. A., Nincic, V., Khan, P. A., Ghassemi, M., Thompson, Y., Lai, Y., Treister, V., Tricco, A. C., & Straus, S. E. (2020). Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: A systematic review and network meta-analysis. BMC Geriatrics, 20. https://doi.org/10.1186/s12877-020-01607-7spa
dc.relation.referencesWHO | The global burden of disease: 2004 update. (s. f.). WHO; World Health Organization. Recuperado 11 de octubre de 2020, de https://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/spa
dc.relation.referencesWilkinson, P., & Izmeth, Z. (2012). Continuation and maintenance treatments for depression in older people. The Cochrane Database of Systematic Reviews, 11, CD006727. https://doi.org/10.1002/14651858.CD006727.pub2spa
dc.relation.referencesWilkinson, P., & Izmeth, Z. (2016). Continuation and maintenance treatments for depression in older people. The Cochrane Database of Systematic Reviews, 9, CD006727. https://doi.org/10.1002/14651858.CD006727.pub3spa
dc.relation.referencesWilson, K. C. M., Mottram, P. G., Ashworth, L., & Abou-Saleh, M. T. (2003). Older community residents with depression: Long-term treatment with sertraline: Randomised, double blind, placebo-controlled study. The British Journal of Psychiatry, 182(6), 492-497. https://doi.org/10.1192/bjp.182.6.492spa
dc.relation.referencesWilson, K., Mottram, P. G., Sivananthan, A., & Nightingale, A. (2001). Antidepressants versus placebo for the depressed elderly. The Cochrane Database of Systematic Reviews, 2001(1). https://doi.org/10.1002/14651858.CD000561spa
dc.relation.referencesWorld Population Prospects—Population Division—United Nations. (s. f.). Recuperado 5 de octubre de 2020, de https://population.un.org/wppspa
dc.relation.referencesZhou, C., Fang, L., Chen, Y., Zhong, J., Wang, H., & Xie, P. (2018). Effect of selective serotonin reuptake inhibitors on bone mineral density: A systematic review and meta-analysis. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 29(6), 1243-1251. https://doi.org/10.1007/s00198-018-4413-0spa
dc.relation.referencesZiere, G., Dieleman, J. P., van der Cammen, T. J. M., Hofman, A., Pols, H. A. P., & Stricker, B. H. C. (2008). Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. Journal of Clinical Psychopharmacology, 28(4), 411-417. https://doi.org/10.1097/JCP.0b013e31817e0ecbspa
dc.contributor.cvlacVillar Centeno, Juan Carlos [0000068519]spa
dc.contributor.orcidVillar Centeno, Juan Carlos [0000-0002-7047-7299]spa
dc.contributor.researchgateVillar Centeno, Juan Carlos [Juan-Carlos-Villar-Centeno-2168464015]spa
dc.subject.lembCiencias médicasspa
dc.subject.lembFarmacologíaspa
dc.subject.lembDrogas psicotrópicasspa
dc.subject.lembPatologíaspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.description.abstractenglishDepression in the elderly is a pathology with high prevalence and complications in a population group in constant growth which entails multiple challenges due to the influence of various biopsychosocial factors that are not present in other population groups. It is associated with a worse prognosis, chronic course, lower antidepressant response and higher risk of relapse or recurrence. The use of antidepressant drugs in the elderly has been correlated with significant adverse effects that could be life-threatening and that must be taken into account when planning treatment. The information that currently exists in guidelines on antidepressant drug treatment is focused on the general population, is not based on evidence or is not synthesized. These present guidelines allow information to be transmitted in a clear, synthesized way, thus health professionals are able to make therapeutic decisions more quickly, avoid complications, prevent inappropriate use of drugs, and improve treatment guidelines for the benefit of the elderly.spa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalAdulto mayorspa
dc.subject.proposalAntidepresivosspa
dc.subject.proposalGuía basada en evidenciaspa
dc.subject.proposalDepresiónspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.description.learningmodalityModalidad Presencialspa


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