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Lamotrigina: evidencia de su utilidad en el trastorno bipolar
dc.contributor.author | Pinzón Amado, Alexánder | spa |
dc.date.accessioned | 2020-10-27T14:22:40Z | |
dc.date.available | 2020-10-27T14:22:40Z | |
dc.date.issued | 2001-09-10 | |
dc.identifier.issn | 2382-4603 | |
dc.identifier.issn | 0123-7047 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12749/10579 | |
dc.description.abstract | Los anticonvulsivantes valproato y carbamazepina han mostrado eficacia en el tratamiento del trastorno bipolar(TB). El anticonvulsivante de segunda generación lamotrigina ha sido reportado como un medicamento que posee efectos antimaníaco, antidepresivo y modulador afectivo. Se han publicado hasta la fecha diversos reportes y series de casos, estudios abiertos y dos ensayos clínicos controlados sobre el uso de la lamotrigina en el TB. La inhibición de los canales de sodio voltaje sensibles, la inhibición en la secreción degluta mato y el bloqueo de los canales de calcio se han propuesto como posibles mecanismos de acción de la lamotrigina para explicar su efecto en la modulación afectiva. El presente artículo revisará los conceptos actuales acerca de la eficacia de la lamotrigina en el tratamiento del TB | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.publisher | Universidad Autónoma de Bucaramanga UNAB | |
dc.relation | https://revistas.unab.edu.co/index.php/medunab/article/view/314/296 | |
dc.relation.uri | https://revistas.unab.edu.co/index.php/medunab/article/view/314 | |
dc.rights.uri | https://gol.caracoltv.com/partidos | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
dc.source | MedUNAB; Vol. 4 Núm. 11 (2001): Leucoria, Ensayos clínicos, Mortalidad neonatal; 107-113 | |
dc.subject | Ciencias biomédicas | |
dc.subject | Ciencias de la vida | |
dc.subject | Innovaciones en salud | |
dc.subject | Investigaciones | |
dc.title | Lamotrigina: evidencia de su utilidad en el trastorno bipolar | spa |
dc.title.translated | Lamotrigine: evidence of its usefulness in bipolar disorder | eng |
dc.publisher.faculty | Facultad Ciencias de la Salud | spa |
dc.publisher.program | Pregrado Medicina | spa |
dc.type.driver | info:eu-repo/semantics/article | |
dc.type.local | Artículo | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | |
dc.subject.keywords | Health Sciences | eng |
dc.subject.keywords | Medicine | eng |
dc.subject.keywords | Medical Sciences | eng |
dc.subject.keywords | Biomedical Sciences | eng |
dc.subject.keywords | Life Sciences | eng |
dc.subject.keywords | Innovations in health | eng |
dc.subject.keywords | Research | eng |
dc.subject.keywords | Lamotrigine | eng |
dc.subject.keywords | Anticonvulsants | eng |
dc.subject.keywords | Bipolar disorder | eng |
dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga UNAB | spa |
dc.type.hasversion | Info:eu-repo/semantics/publishedVersion | |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.relation.references | Goodwin FK, Jamison KR. Manic Depressive Illness. New York,NY: Oxford University Press; 1990 | spa |
dc.relation.references | American Psychiatric Association. Diagnostic and statisticalmanual of mental disorders. 4th ed. Washington (DC): 1994 | spa |
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dc.relation.references | Goldberg J, Harrow M. Poor-outcome bipolar disorders. En Bipolardisorders: Clinical course and outcome, Goldberg J, Harrow M.Editors, American Psychiatric Press, Washington D.C., 1999 | spa |
dc.relation.references | Woods S. The economic burden of bipolar disease. J ClinPsychiatry 2000; 61 (Suppl 13): 38-41. | spa |
dc.relation.references | Calabrese J, Bowden C, Woyshville M. Lithium and theanticonvulsants in the treatment of bipolar disorder. EnPsychopharmacology: The Fourth Generation of Progress,Blomm F. and Kupfer D. Editors, Raven Press, New York, 1995 | spa |
dc.relation.references | Work Group on Bipolar Disorder. Practice guideline for treatmentof patients with bipolar disorder. In American PsychiatricAssociation Practice Guidelines. American Psychiatric Press,Washington D.C., 1996 | spa |
dc.relation.references | Calabrese J, Woyshwille M. Lithium therapy: Limitations andalternatives in the treatment of bipolar disorders. Ann ClinPsychiatr 1995; 7 (2): 103-12 | spa |
dc.contributor.cvlac | Pinzón Amado, Alexánder [0000328758] | spa |
dc.contributor.googlescholar | Pinzón Amado, Alexánder [cdDLVRQAAAAJ&hl=es&oi=ao] | spa |
dc.contributor.orcid | Pinzón Amado, Alexánder [0000-0002-4369-9603] | spa |
dc.subject.lemb | Ciencias de la salud | spa |
dc.subject.lemb | Ciencias médicas | spa |
dc.subject.lemb | Medicina | spa |
dc.identifier.repourl | repourl:https://repository.unab.edu.co | |
dc.description.abstractenglish | The anticonvulsants valproate and carbamazepine have shown efficacy in the treatment of bipolar disorder (TB). The second-generation anticonvulsant lamotrigine has been reported as a medication that has antimanic, antidepressant, and affective modulating effects. To date, various reports and case series, open studies and two controlled clinical trials have been published on the use of lamotrigine in TB. Inhibition of voltage-sensitive sodium channels, inhibition of swallowing secretion and blockade of calcium channels have been proposed as possible mechanisms of action of lamotrigine to explain its effect on affective modulation. This article will review current concepts about the effectiveness of lamotrigine in the treatment of TB. | eng |
dc.subject.proposal | Lamotrigina | spa |
dc.subject.proposal | Anticonvulsivantes | spa |
dc.subject.proposal | Trastorno bipolar | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/ART |
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