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Ciclooxigenasa 3: La nueva iso-enzima en la familia

dc.contributor.authorPradilla Vesga, Oscar Enriquespa
dc.date.accessioned2020-10-27T14:21:55Z
dc.date.available2020-10-27T14:21:55Z
dc.date.issued2004-12-04
dc.identifier.issn2382-4603
dc.identifier.issn0123-7047
dc.identifier.urihttp://hdl.handle.net/20.500.12749/10464
dc.description.abstractEn 2002 Simmons y colaboradores, de la Universidad Brigham Young de Estados Unidos identificaron una nueva isoforma de ciclooxigenasa la cual fue denominada ciclooxigenasa-3. Esta deriva del gen que codifica la ciclooxigenasa-1, pero es estructural y funcionalmente distinta. Se estableció que su papel es a nivel de la producción de la fiebre, el dolor a nivel central y no a nivel de la inflamación. Al evaluar los medicamentos que producen inhibición farmacológica se identificó al acetaminofén como el más selectivo hacia ella y secundario a estos hallazgos luego de casi 60 años se esclareció el mecanismo de acción de este medicamento.[Pradilla OE. Ciclooxigenasa 3: La nueva iso-enzima en la familia. MedUNAB 2004; 7: 181-4].spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Autónoma de Bucaramanga UNAB
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/216/199
dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/article/view/216
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceMedUNAB; Vol. 7 Núm. 21 (2004): TDAH, Tuberculosis, Trypanosoma Rangeli; 181-184
dc.subjectCiencias biomédicas
dc.subjectCiencias de la vida
dc.subjectInnovaciones en salud
dc.subjectInvestigaciones
dc.titleCiclooxigenasa 3: La nueva iso-enzima en la familiaspa
dc.title.translatedCyclooxygenase 3: the new iso-enzyme in the familyeng
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.programPregrado Medicinaspa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.localArtículospa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.subject.keywordsHealth Scienceseng
dc.subject.keywordsMedicineeng
dc.subject.keywordsMedical Scienceseng
dc.subject.keywordsBiomedical Scienceseng
dc.subject.keywordsLife Scienceseng
dc.subject.keywordsInnovations in healtheng
dc.subject.keywordsResearcheng
dc.subject.keywordsCyclooxygenaseeng
dc.subject.keywordsCyclooxygenase-3eng
dc.subject.keywordsAcetaminopheneng
dc.subject.keywordsPaineng
dc.subject.keywordsFevereng
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.type.hasversionInfo:eu-repo/semantics/publishedVersion
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.relation.referencesWilloughby DA, Moore AR, Colville-Nash PR. COX-1, COX-2, and COX-3 and the future treatment of chronic infl ammatory disease. Lancet 2000; 355:646–48spa
dc.relation.referencesThe Nobel Foundation. Press release: The 1982 Nobel Prize in physiology or medicine. Disponible en URL: http://nobelprize.org/medicine/laureates/1982/press.htmleng
dc.relation.referencesThe Nobel Foundation. Jhon R. Vane-Autobyography. Disponible en URL: http://nobelprize.org/medicine/laureates/1982/vane-autobio.htmleng
dc.relation.referencesDavis S. Canine brains express new COX enzyme. DVM 2002,33(11):10S. Disponible en URL: http://dvm.adv100.com/dvm/article/articleDetail.jsp?id=39056eng
dc.relation.referencesSchwab JM, Schluesener HJ, Laufer S. COX-3: Just another COX or the solitary elusive target of paracetamol? Lancet 2003;361:981-2eng
dc.relation.referencesAyoub SS, Botting RM, Goorha S, Covile-Nash PR, Willoughby DA, Ballou LR. Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxid synthase 1 gene-derived protein. PNAS 2004; 101:11165-11169spa
dc.relation.referencesHawkey CJ. Cyclooxygenase inhibition: Between the devil and the deep blue sea. Gut 2002;50(Suppl III):iii25–iii30spa
dc.relation.referencesWickelgren I. Enzime might relieve research headache. Science 2002; 297(5589): 1976.eng
dc.relation.referencesHenry C. COX-3 Found. Chem Eng News 2002; 80(38):3eng
dc.relation.referencesSenior K. Homing in on COX-3 – The elusive target of parace-tamol. Lancet Neurol 2002;1(7):399eng
dc.relation.referencesWarner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?. PNAS 2002; 99:13371-13373eng
dc.subject.lembCiencias de la saludspa
dc.subject.lembMedicinaspa
dc.subject.lembCiencias médicasspa
dc.identifier.repourlrepourl:https://repository.unab.edu.co
dc.description.abstractenglishIn 2002 Simmons et al., from Brigham Young University in the United States, identified a new cyclooxygenase isoform which was named cyclooxygenase-3. This is derived from the gene encoding cyclooxygenase-1, but is structurally and functionally different. It was established that its role is at the level of the production of fever, pain at the central level and not at the level of inflammation. When evaluating the drugs that produce pharmacological inhibition, acetaminophen was identified as the most selective towards it and secondary to these findings after almost 60 years the mechanism of action of this drug was clarified.[Pradilla OE. Cyclooxygenase 3: The new iso-enzyme in the family. MedUNAB 2004; 7:181-4].eng
dc.subject.proposalCiclooxigenasaspa
dc.subject.proposalCiclooxigenasa-3spa
dc.subject.proposalCOX-3spa
dc.subject.proposalAcetaminofénspa
dc.subject.proposalDolorspa
dc.subject.proposalFiebrespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ART


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