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Influencia de los factores genéticos y medioambientales en la susceptilidad para desarrollar preeclampsia
dc.contributor.author | Serrano Díaz, Norma Cecilia | spa |
dc.contributor.author | Díaz Martínez, Luis Alfonso | spa |
dc.date.accessioned | 2020-10-27T14:21:46Z | |
dc.date.available | 2020-10-27T14:21:46Z | |
dc.date.issued | 2005-08-03 | |
dc.identifier.issn | 2382-4603 | |
dc.identifier.issn | 0123-7047 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12749/10437 | |
dc.description.abstract | La preeclampsia se presenta en todas las poblaciones del mundo, con incidencia del 5-7%; sin embargo, en países en vía de desarrollo puede ser tres veces mayor. En Colombia es la primera causa de de morbilidad y mortalidad materna, siendo un problema de salud pública. La etiología de la PE permanece aún por esclarecer, pero se acepta que es una enfermedad compleja, en la cual la manifestación individual de la enfermedad depende de la interacción de efectos genéticos maternos y fetales y factores medioambientales. Recientemente se ha intentado calcular el peso de cada uno de estos factores sobre la predisposición a desarrollar la enfermedad. Los factores genéticos tanto maternos como fetales contribuyen en un 50% a explicar esta susceptibilidad. Los resultados generados por el estudio colombiano de genes candidatos en PE, GenPE, ratifican estos hallazgos, al encontrar que el tener el antecedente de madre o hermana con PE son factores de riesgo independientes para desarrollar esta patología con OR de 2.74 (IC 95% 1.96-3.83) y 2.37 (IC 95% 1.54-2.63), respectivamente). [Serrano NC, Díaz LA. Influencia de los factores genéticos y medioambientales en la susceptibilidad para desarrollar preeclampsia. MedUNAB 2005; 8:159-163]. | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.publisher | Universidad Autónoma de Bucaramanga UNAB | |
dc.relation | https://revistas.unab.edu.co/index.php/medunab/article/view/3141/2641 | |
dc.relation.uri | https://revistas.unab.edu.co/index.php/medunab/article/view/3141 | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
dc.source | MedUNAB; Vol. 8 Núm. 2 (2005): Especial Salud de la Mujer; 159-164 | |
dc.subject | Ciencias médicas | |
dc.subject | Innovaciones en salud | |
dc.subject | Investigaciones | |
dc.title | Influencia de los factores genéticos y medioambientales en la susceptilidad para desarrollar preeclampsia | |
dc.title.translated | Influence of genetic and environmental factors on susceptibility to develop preeclampsia | |
dc.publisher.faculty | Facultad Ciencias de la Salud | |
dc.publisher.program | Pregrado Medicina | |
dc.type.driver | info:eu-repo/semantics/article | |
dc.type.local | Artículo | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | |
dc.subject.keywords | Health Sciences | eng |
dc.subject.keywords | Medicine | eng |
dc.subject.keywords | Medical Sciences | eng |
dc.subject.keywords | Biomedical Sciences | eng |
dc.subject.keywords | Life Sciences | eng |
dc.subject.keywords | Innovations in health | eng |
dc.subject.keywords | Research | eng |
dc.subject.keywords | Preeclampsia | |
dc.subject.keywords | Gestational hypertension | |
dc.subject.keywords | Genetics | |
dc.subject.keywords | Heredability | |
dc.subject.keywords | Twins study | |
dc.subject.keywords | Recurrence risk | |
dc.subject.keywords | Environment | |
dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga UNAB | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
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dc.relation.references | errano N, Páez C, Martínez MP, Casas JP, Gil L, Navarro AA. Bases genéticas y moleculares de la preeclampsia. MedUNAB 2002: 5:185-94 | |
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dc.relation.references | Serrano NC, Correa PA, Anaya JM. Introducción al estudio genético de las enfermedades autoinmunes. En: Anaya JM, Schoenfeld Y, Correa PA, García-Carrasco M, Cervera R (eds). Autoinmunidad y enfermedad autoinmune. Medellín, CIB, 2005:191-202 | |
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dc.relation.references | Salonen Ros H, Lichtenstein P, Lipworth L, Cnattingius S. Ge-netic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Hum Genet 2000; 91:256-60 | |
dc.relation.references | Neale MC, Boker SM, Xie G, Maes HH. Mx: Statiscal Modeling, 5th edition. Richmond, Virginia: Virginia Commonwealth Univer-sity, 1999 | |
dc.relation.references | Nilsson E, Salonen Ros H, Cnattingius S, Lichtenstein P. The importance of genetic and environmental effects for pre-eclamp-sia and gestational hypertension: a family study. Br J Obstet Gynecol 2004; 111:200-6 | |
dc.relation.references | Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM. Fetal and maternal contributions to risk of preeclamp-sia: population based study. Br Med J 1998: 316:1343-7 | |
dc.relation.references | Esplin MS, Fausett B, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW. Paternal and maternal components of the predis-position to preeclampsia. N Engl Med 2001; 344:867-72 | |
dc.relation.references | Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P. Maternal and fetal genetic factors account for most of familial aggregation on preeclampsia. Am J Med Genet 2004;130A:365-71 | |
dc.relation.references | Serrano N, Casas JP, Díaz LA, Páez MC, Mesa CM, Cifuentes R, et al. Endothelial nitric oxide synthase genotype and risk of preeclampsia: a multi-centre case-control study. Hypertension 2004; 44:702-7 | |
dc.relation.references | Serrano NC, Casas JP, Díaz LA, Páez MC, Millán PA, Monter-rosa A, et al. Evidencia a gran escala de la no asociación entre el polimorfismo inserción/delección (I/D) del gen de la enzima convertidora de angiotensina (ECA) y preeclampsia. XVIII Con-greso Latino-Americano de Ginecología y Obstetricia. República Dominicana, Mayo 15-21, 2005 | |
dc.contributor.cvlac | Serrano Díaz, Norma Cecilia [0000066613] | |
dc.contributor.cvlac | Díaz Martínez, Luis Alfonso [0000066621] | |
dc.contributor.googlescholar | Díaz Martínez, Luis Alfonso [ABarFDsAAAAJ] | |
dc.contributor.orcid | Serrano Díaz, Norma Cecilia [0000-0003-3532-2002] | |
dc.contributor.orcid | Díaz Martínez, Luis Alfonso [0000-0002-4498-6639] | |
dc.contributor.scopus | Serrano Díaz, Norma Cecilia [7003706613] | |
dc.subject.lemb | Ciencias de la salud | |
dc.subject.lemb | Medicina | |
dc.subject.lemb | Ciencias biomédicas | |
dc.subject.lemb | Ciencias de la vida | |
dc.identifier.repourl | repourl:https://repository.unab.edu.co | |
dc.description.abstractenglish | How genetically or environmental factors may affect the development of preeclampsia? Preeclampsia presents itself in all of the world’s populations, with an incidence of 5 – 7%; however in developing countries it can be three times greater. In Colombia it is the primary cause of maternal morbidity and mortality, being a problem of public health. Ethiology of PE is still unknown but it’s accepted that it is a complex disease where individual manifes-tations depends on the interaction of maternal and fetal genetics and environmental factors. Recently the influence of each of these factors on predisposition to develop the disease has tried to be measured. Genetic factors, maternal and fetal, contribute 50% towards susceptibility to the condition. General results by a study on Colombian candidate genes in PE, GenPE, support these findings, having found the having a familiar history of PE (i.e. mother, sister) are independent risk factors to develop the pathology with OR of 2.74 (IC 95% 1.96-3.83) and 2.37 (IC 95% 1.54-2.63), respectively | eng |
dc.subject.proposal | Preeclampsia | |
dc.subject.proposal | Hipertensión gestacional | |
dc.subject.proposal | Genética | |
dc.subject.proposal | Heredabilidad | |
dc.subject.proposal | Estudio en gemelos | |
dc.subject.proposal | Riesgo de recurrencia | |
dc.subject.proposal | Medioambiente | |
dc.type.redcol | http://purl.org/redcol/resource_type/ART | |
dc.contributor.researchgroup | Grupo de Estudio Genético de Enfermedades Complejas | spa |
dc.contributor.researchgroup | Grupo de Investigación en Neuropsiquiatría | spa |
dc.contributor.researchgroup | Grupo de Investigaciones Clínicas | spa |