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dc.contributor.authorCastaneda, Camilospa
dc.contributor.authorPantoja, María Camilaspa
dc.contributor.authorMontaño, Luzmilaspa
dc.contributor.authorRosselli, Diegospa
dc.description.abstractEl mieloma múltiple es un tumor maligno y progresivo de las células B asociado a lesiones osteolíticas, inmunodeficiencia y disfunción renal que ha sido tratado desde 2008 con bortezomib con el cual se logró un aumento del tiempo de sobrevida de los pacientes, sin embargo su uso se vio limitado por efectos adversos dependientes de la dosis, en especial la neuropatía periférica dolorosa. Recientemente ha entrado en uso carfilzomib (agente inhibidor de proteosoma de segunda generación) aprobado por la FDAen 2012 como agente único para tratamiento de enfermedad refractaria y recaídas de mieloma mú
dc.publisherUniversidad Autónoma de Bucaramanga UNAB
dc.sourceMedUNAB; Vol. 17 Núm. 2 (2014): Agosto - Noviembre de 2014: Mieloma múltiple, Aloinmunización eritrocitaria, Riesgo cardiovascular; 99-106
dc.titleCarfilzomib en el tratamiento de mieloma múltiple: revisión sistemática de la literatura y experiencia colombiana basada en RIPS
dc.title.translatedCarfilzomib for the treatment of multiple myeloma: systematic review of the literature and colombian experience based on RIPSeng
dc.title.translatedCarfilzomib no tratamento do mieloma múltiplo: revisão da literatura e da experiência colombiana baseada em RIPS
dc.publisher.facultyFacultad Ciencias de la Salud
dc.publisher.programPregrado Medicina
dc.subject.keywordsMultiple myelomaeng
dc.subject.keywordsProteosome inhibitorseng
dc.subject.keywordsMieloma múltiploeng
dc.subject.keywordsInibidores de proteassomaeng
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
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dc.subject.lembCiencias de la salud
dc.subject.lembCiencias de la vida
dc.description.abstractenglishMultiple myeloma is a malignant and progressive B-cell tumor associated with osteolytic lesions, immunodeficiency and renal dysfunction that has been treated with bortezomib since 2008, with which an increase in the survival time of patients was achieved, however its use is was limited by dose-dependent adverse effects, especially painful peripheral neuropathy. Recently, carfilzomib (a second-generation proteasome inhibitor agent) approved by the FDA in 2012 as a single agent for the treatment of refractory disease and relapses of multiple myeloma has come into use.eng
dc.subject.proposalInibidores de proteassoma

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