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"Cardiovascular health investigation and collaboration to assess the markers and outcomes of Chagas disease" (CHICAMOCHA): concepto, métodos y características de una cohorte de donantes de sangre en Bucaramanga, Colombia
dc.contributor.author | Villar Centeno, Juan Carlos | spa |
dc.contributor.author | Herrera Galindo, Victor Mauricio | spa |
dc.contributor.author | Chávez Neira, Ángel María | spa |
dc.contributor.author | Martínez Contreras, Luz Ximena | spa |
dc.contributor.author | Villar Centeno, Luis Ángel | spa |
dc.contributor.author | Ardila, Elizabeth | spa |
dc.contributor.author | Vásquez Hernández, Skarlet Marcell | spa |
dc.contributor.author | Vásquez, Martha | spa |
dc.date.accessioned | 2020-10-27T14:20:02Z | |
dc.date.available | 2020-10-27T14:20:02Z | |
dc.date.issued | 2015-04-12 | |
dc.identifier.issn | 2382-4603 | |
dc.identifier.issn | 0123-7047 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12749/10115 | |
dc.description.abstract | Colombia está expuesta simultáneamente a las enfermedades transmitidas por vectores como la Enfermedad de Chagas (ECHA), asÍ como a la carga creciente de la enfermedad cardiovascular de origen aterosclerótico (ECV). Objetivo: Estudiar a través del ensamblaje de un estudio de cohorte de adultos jóvenes de Bucaramanga, el desarrollo de la ECHA y la ECV. MetodologÍa: Se diseñó un estudio a partir de donantes de sangre con tamización serológica para T. cruzi. Se construyó una base de datos de donantes consecutivos con estatus positivo (T[+]) apareada (en relación 1:4, estratificada por banco y mes de donación) con donantes T[-]. Los participantes fueron clasificados por estado serológico y electrocardiograma y evaluados clÍnicamente (realizando pruebas adicionales de función cardiovascular a los T[+] y a una muestra aleatoria de T[-]). En los siguientes años se iniciaron ensayos clÍnicos en los participantes T[+] y mediciones repetidas en los T[-] para estudios de riesgo de ECV. Resultados: De 6,228 donantes (18 a 50 años de edad) registrados en la base (1997-2003), 2,130 donantes de sangre (edad media 36.4 [DE 8.4] años, 64.0% hombres, 73.4% residentes en los estratos 1-3, 486 T[+]) consintieron participar. El protocolo de contacto, seguimiento y recuperación de participantes ha logrado que se obtengan mediciones repetidas en al menos el 80% de los participantes. Conclusiones: CHICAMOCHA constituye un activo de valor social que aumenta las capacidades locales de investigación. Se requieren esfuerzos continuados para ensanchar sus posibilidades de formación de investigadores, g e n e r a c i ó n d e p r o d u c t o s d e c o n o c i m i e n t o y recomendaciones para el sistema de salud.[Villar JC, Herrera VM, Cháves-Neira AM, MartÍnez-Contreras LX, Villar-Centeno LA, Ardila E, Marcell-Vásquez S, Vásquez SM. "Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease " (CHICAMOCHA): Concepto, métodos y caracterÍsticas de una cohorte de donantes de sangre en Bucaramanga, Colombia. MedUNAB 2015; 18 (1): 14-26] | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.publisher | Universidad Autónoma de Bucaramanga UNAB | |
dc.relation | https://revistas.unab.edu.co/index.php/medunab/article/view/2311/2053 | |
dc.relation.uri | https://revistas.unab.edu.co/index.php/medunab/article/view/2311 | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
dc.source | MedUNAB; Vol. 18 Núm. 1 (2015): Abril - Julio de 2015: Enfermedad Chagas, Leucemia linfoide, Cuidadores familiares; 14-26 | |
dc.subject | Donantes de sangre | |
dc.subject | Enfermedad de Chagas | |
dc.subject | Trypanosoma cruzi | |
dc.subject | Serología | |
dc.subject | Factores de Riesgo | |
dc.subject | Enfermedad Crónica | |
dc.subject | Blood Donors | |
dc.subject | Chagas Disease | |
dc.subject | Serology | |
dc.subject | Risk Factors | |
dc.subject | Doadores de Sangue | |
dc.subject | Doença de Chagas | |
dc.subject | Sorologia | |
dc.subject | Fatores de Risco | |
dc.title | "Cardiovascular health investigation and collaboration to assess the markers and outcomes of Chagas disease" (CHICAMOCHA): concepto, métodos y características de una cohorte de donantes de sangre en Bucaramanga, Colombia | |
dc.title.translated | "Cardiovascular health investigation and collaboration to assess the markers and outcomes of Chagas disease” (CHICAMOCHA): Concept, Methods and Characteristics of a Cohort of Blood Donors in Bucaramanga, Colombia | |
dc.title.translated | “Pesquisa de sáudes cardiovascular e colaborcao para evaliar os marcadores e os resultados da foeca da Chagas”: coceito, metordos e características de grupo de doadores de sagre em Bucaramanga, Colombia | |
dc.publisher.faculty | Facultad Ciencias de la Salud | |
dc.publisher.program | Pregrado Medicina | |
dc.type.driver | info:eu-repo/semantics/article | |
dc.type.local | Artículo | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | |
dc.subject.keywords | Blood donors | |
dc.subject.keywords | Chagas disease | |
dc.subject.keywords | Trypanosoma cruzi | |
dc.subject.keywords | Serology | |
dc.subject.keywords | Risk factors | |
dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga UNAB | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
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dc.contributor.cvlac | Villar Centeno, Juan Carlos [0000068519] | |
dc.contributor.cvlac | Herrera Galindo, Victor Mauricio [0000068020] | |
dc.contributor.cvlac | Martínez Contreras, Luz Ximena [0000018589] | |
dc.contributor.cvlac | Vásquez Hernández, Skarlet Marcell [0001349039] | |
dc.contributor.googlescholar | Villar Centeno, Juan Carlos [nTlsWe0AAAAJ] | |
dc.contributor.googlescholar | Herrera Galindo, Victor Mauricio [ay0xprEAAAAJ] | |
dc.contributor.googlescholar | Vásquez Hernández, Skarlet Marcell [IyVfYugAAAAJ] | |
dc.contributor.orcid | Villar Centeno, Juan Carlos [0000-0002-7047-7299] | |
dc.contributor.orcid | Herrera Galindo, Victor Mauricio [0000-0002-6295-1640] | |
dc.contributor.orcid | Vásquez Hernández, Skarlet Marcell [0000-0003-2552-9819] | |
dc.subject.lemb | Patología | |
dc.subject.lemb | Medicina | |
dc.subject.lemb | Diagnósticos | |
dc.identifier.repourl | repourl:https://repository.unab.edu.co | |
dc.description.abstractenglish | Geographical and socio-demographic conditions expose Colombian population to the threat of vector-borne diseases (such as Chagas’ [CHAD]) and cardiovascular disease of atherosclerotic origin (CVD). Objective: To assemble a cohort study of young adults, to promote understanding of CHAD and CVD in Bucaramanga, Colombia. Methodology: A study of blood donors with serological screening for T.cruzi was designed. A database of consecutive donors with positive results (T[+]) was built. This group was compared with a random sample of T[-] individuals (1:4 ratio, within strata of bank and month of donation). Participants classified by serology and electrocardiography status underwent clinical interviews (additional cardiovascular tests to T[+] and a random sample to T[-] were performed. In the following years, T[+] individuals participated in randomized trials whereas those whereas those T[-] participated in repeated measurements to test CVD risk factors. Results: From 6,228 donors in the database (18 to 50 years old) registered in the database (1997-2203), 2,130 blood donors (mean age 36.4 (SD 8.4) years, 64% males, 73.4% living in low socioeconomic strata, 486 T[+]) agreed to participate. Our contact protocol, and follow-up procedure with participants allowed us to obtain repeatedly measurements of at least 80% of the participants. Conclusions: CHICAMOCHA represents a social asset that builds local research capacity. Continued efforts are required to enhance its potential for research training, scholarly work and health care guidance. [Villar JC, Herrera VM, Cháves-Neira AM, MartÍnez-Contreras LX, Villar-Centeno LA, Ardila E, Marcell-Vásquez S, Vásquez SM. "Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease " (CHICAMOCHA): Concept, methods and characteristics of a cohort of blood donors in Bucaramanga, Colombia. MedUNAB 2015; 18 (1): 14-26] | eng |
dc.subject.proposal | Donantes de sangre | |
dc.subject.proposal | Enfermedad de Chagas | |
dc.subject.proposal | Trypanosoma cruzi | |
dc.subject.proposal | Serología | |
dc.subject.proposal | Factores de riesgo | |
dc.identifier.doi | 10.29375/01237047.2311 | |
dc.type.redcol | http://purl.org/redcol/resource_type/ART | |
dc.contributor.researchgroup | Grupo de Investigación en Cardiología Preventiva | spa |
dc.contributor.researchgroup | Grupo de Investigaciones Clínicas | spa |